Isoforms of elongation factor eEF1A may be differently regulated at post-transcriptional level in breast cancer progression

• Published in: Вiopolymers and Cell
• Date: 2013
• Main Authors: Vislovukh, A.A., Naumovets, M.G., Kovalenko, M.I., Groisman, R.S., Groisman, I.S., Negrutskii, B.S., El'skaya, A.V.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2013
• Subjects: Genomics, Transcriptomics and Proteomics
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/152495
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Isoforms of elongation factor eEF1A may be differently regulated at post-transcriptional level in breast cancer progression / A.A. Vislovukh, M.G. Naumovets, M.I. Kovalenko, R.S. Groisman, I.S. Groisman, B.S. Negrutskii, A.V. El'skaya // Вiopolymers and Cell. — 2013. — Т. 29, №. 1. — С. 55-63. — Бібліогр.: 56 назв. — англ.

Eukaryotic translation elongation factor 1A exists as two 98 % homologous isoforms: eEF1A1 (A1) and eEF1A2 (A2) which are tissue and development specific. Despite high homology in an open reading frame (ORF) region, mRNAs coding for eEF1A1 and eEF1A2 are different in their untranslated regions (UTR)...