MGMT expression: insights into its regulation. 1. Epigenetic factors

• Published in: Вiopolymers and Cell
• Date: 2013
• Main Author: Iatsyshyna, A.P.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2013
• Subjects: Reviews
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/152497
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: MGMT expression: insights into its regulation. 1. Epigenetic factors / A.P. Iatsyshyna // Вiopolymers and Cell. — 2013. — Т. 29, №. 2. — С. 99-106. — Бібліогр.: 52 назв. — англ.

O⁶-methylguanine-DNA methyltransferase (MGMT) is the DNA repair enzyme responsible for removing of alkylation adducts from the O6-guanine in DNA. Despite MGMT prevents mutations and cell death, this enzyme can provide resistance of cancer cells to alkylating agents of chemotherapy. The high intra- a...