Autoantibodies against tyrosyl-tRNA synthetase and its separated domains at essential hypertension

• Date: 2015
• Main Authors: Grom, M.Yu., Yakovenko, L.F., Granich, V.M., Dobrohod, A.S., Torbas, O.O., Radchenko, A.D., Sirenko, Yu.M., Sidorik, L.L., Kornelyuk, A.I.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2015
• Series: Вiopolymers and Cell
• Subjects: Biomedicine
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/152568
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Autoantibodies against tyrosyl-tRNA synthetase and its separated domains at essential hypertension / M.Yu. Grom, L.F. Yakovenko, V.M. Granich, A.S. Dobrohod, O.O. Torbas, A.D. Radchenko, Yu.M. Sirenko, L.L. Sidorik, A.I. Kornelyuk // Вiopolymers and Cell. — 2015. — Т. 31, № 4. — С. 255-263. — Бібліогр.: 47 назв. — англ.

In addition to the key role in biosynthesis some aminoacyl-tRNA synthetases provide non-canonical functions. Particularly, separated fragments of tyrosyl-tRNA synthetase (TyrRS) involved into angiogenesis and inflammation. Meanwhile, the vascular inflammation and endothelial dysfunction are central...