Design and study of telomerase inhibitors based on G-quadruplex ligands

• Published in: Вiopolymers and Cell
• Date: 2013
• Main Authors: Negrutska, V.V., Dubey, L.V., Ilchenko, M.M., Dubey, I.Ya.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2013
• Subjects: Reviews
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/152572
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Design and study of telomerase inhibitors based on G-quadruplex ligands / V.V. Negrutska, L.V. Dubey, M.M. Ilchenko, I.Ya. Dubey // Вiopolymers and Cell. — 2013. — Т. 29, №. 3. — С. 169-176. — Бібліогр.: 39 назв. — англ.

In this review we have summarized the results of our recent research on telomerase inhibitors and G-quadruplex DNA ligands. A series of potential enzyme inhibitors were synthesized and studied. These compounds were based on tricyclic heteroaromatic systems (thiazolobenzimidazoles phenazines, acridon...