Colocalization of cortactin and PH domain of BCR in HEK293T cells and its potential role in cell signaling

• Published in: Вiopolymers and Cell
• Date: 2016
• Main Authors: Gurianov, D.S., Antonenko, S.V., Telegeev, G.D.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2016
• Subjects: Structure and Function of Biopolymers
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/152764
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Colocalization of cortactin and PH domain of BCR in HEK293T cells and its potential role in cell signaling / D.S. Gurianov, S.V. Antonenko, G.D. Telegeev // Вiopolymers and Cell. — 2016. — Т. 32, № 1. — С. 26-33. — Бібліогр.: 34 назв. — англ.

Chromosomal translocation t(9;22)(q34;q11) leads to the generation of different types of the BCR-ABL fusion protein and cause different types of leukemias. The generated fusion proteins differ by the presence or absence of certain domains of BCR – C2, PH, and DH. The mass-spectrometric analysis iden...