Molecular docking and molecular dynamics simulation studies on Thermus thermophilus leucyl-tRNA synthetase complexed with different amino acids and pre-transfer editing substrates

• Published in: Вiopolymers and Cell
• Date: 2016
• Main Authors: Rayevsky, A.V., Tukalo, M.A.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2016
• Subjects: Bioinformatics
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/152770
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Molecular docking and molecular dynamics simulation studies on Thermus thermophilus leucyl-tRNA synthetase complexed with different amino acids and pre-transfer editing substrates / A.V. Rayevsky, M.A. Tukalo // Вiopolymers and Cell. — 2016. — Т. 32, № 1. — С. 61-69. — Бібліогр.: 24 назв. — англ.

Aim. To investigate the structural bases for the amino acid selectivity of the Thermus thermophilus leucyl-tRNA synthetase (LeuRSTT) aminoacylation site and to disclose the binding pattern of pre-transfer editing substrates. Methods. Eight amino acids proposed as semi-cognate substrates for aminoacy...