Molecular docking and molecular dynamics simulation studies on Thermus thermophilus leucyl-tRNA synthetase complexed with different amino acids and pre-transfer editing substrates

• Опубліковано в: : Вiopolymers and Cell
• Дата: 2016
• Автори: Rayevsky, A.V., Tukalo, M.A.
• Формат: Стаття
• Мова: English
• Опубліковано: Інститут молекулярної біології і генетики НАН України 2016
• Теми: Bioinformatics
• Онлайн доступ: https://nasplib.isofts.kiev.ua/handle/123456789/152770
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Цитувати: Molecular docking and molecular dynamics simulation studies on Thermus thermophilus leucyl-tRNA synthetase complexed with different amino acids and pre-transfer editing substrates / A.V. Rayevsky, M.A. Tukalo // Вiopolymers and Cell. — 2016. — Т. 32, № 1. — С. 61-69. — Бібліогр.: 24 назв. — англ.

Aim. To investigate the structural bases for the amino acid selectivity of the Thermus thermophilus leucyl-tRNA synthetase (LeuRSTT) aminoacylation site and to disclose the binding pattern of pre-transfer editing substrates. Methods. Eight amino acids proposed as semi-cognate substrates for aminoacy...