RNAse L and genome expression during early period of the rat liver regeneration

• Date: 2000
• Main Authors: Obolenskaya, M.Yu., Sazonova, L.Ya., Gerasimova, T.B., Rybalko, S.L., Bisbal, C.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2000
• Series: Биополимеры и клетка
• Subjects: Структура и функции биополимеров
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/152829
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: RNAse L and genome expression during early period of the rat liver regeneration / M.Yu. Obolenskaya, L.Ya Sazonova, T.B. Gerasimova, S.L. Rybalko, C. Bisbal // Биополимеры и клетка. — 2000. — Т. 16, № 5. — С. 380-383. — Бібліогр.: 12 назв. — англ.

Partial hepatectomy (PHE) stimulates an intact part of the liver to exchange the existing «quiescence» program for the proliferative one. Several changes between 0.5 and 3 h after PHE are considered as manifestations of the abolishment of «quiescence» program: a temporal decrease of either UNA synthesis or accumulation of the newly formed RNA; a restricted variability of RNA transcripts; a partial retention of newly synthesized RNA within the nuclei thereby providing less RNA for the cytoplasm; previously obtained data about transient dissociation of ribosomes from endoplasmic reticulum. An involvement of the 2',5'-oligo(A)synthetase–RNAse L system in the process is suggested by up- and down-regulation of 2',5'-oligo(A)synthetase activity in the cytoplasm and in the nucleus, respectively, and by up-regulation of RNAse L content in regenerating liver. The production of IFN α/β, an inducer of the 2',5'-oligo(A)synthetase–RNAse L system, is also increased during transition period. A specific role of sinusoidal cells, the main producers of IFN α/β m the liver, in the abolishment of the old program is strongly suggested.