Telomerase inhibition by new di- and trisubstituted acridine derivatives

• Veröffentlicht in: Вiopolymers and Cell
• Datum: 2016
• Hauptverfasser: Negrutska, V.V., Saraieva, I.V., Kostina, V.G., Alexeeva, I.V., Lysenko, N.A., Dubey, I.Ya.
• Format: Artikel
• Sprache: English
• Veröffentlicht: Інститут молекулярної біології і генетики НАН України 2016
• Schlagworte: Short Communications
• Online Zugang: https://nasplib.isofts.kiev.ua/handle/123456789/152861
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Zitieren: Telomerase inhibition by new di- and trisubstituted acridine derivatives / V.V. Negrutska, I.V. Saraieva, V.G. Kostina, I.V. Alexeeva, N.A. Lysenko, I.Ya. Dubey // Вiopolymers and Cell. — 2016. — Т. 32, № 6. — С. 468-471. — Бібліогр.: 16 назв. — англ.

Aim. To study a series of new acridine derivatives containing two basic fragments able to bind to quadruplex DNA at C-4 and C-9 positions as potential telomerase inhibitors. Methods. TRAP assay was used to determine the activity of compounds in vitro. Results. A number of acridines inhibiting the en...