Aberrant DNA glycosylase-initiated repair pathway of free radicals in-duced DNA damage: implications for age-related diseases and natural aging

• Published in: Вiopolymers and Cell
• Date: 2017
• Main Authors: Matkarimov, B.T., Saparbaev, M.K.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2017
• Subjects: Reviews
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/152878
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Aberrant DNA glycosylase-initiated repair pathway of free radicals in-duced DNA damage: implications for age-related diseases and natural aging / B.T. Matkarimov, M.K. Saparbaev // Вiopolymers and Cell. — 2017. — Т. 33, № 1. — С. 3-23. — Бібліогр.: 118 назв. — англ.

Aerobic cellular respiration generates reactive oxygen species (ROS), which can damage macro-molecules including lipids, proteins and DNA. It was proposed that aging is a consequence of accumulation of naturally occurring unrepaired oxidative DNA damage. In human cells, approximately 2000 to 8000 DN...