Screening of spiro-substituted thiopyrano[2,3-d]thiazoles for their cytotoxic action on tumor cells

• Published in: Вiopolymers and Cell
• Date: 2017
• Main Authors: Zelisko, N.I., Finiuk, N.S., Shvets, V.M., Medvid, Yu.O., Stoika, R.S., Lesyk, R.B.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2017
• Subjects: Bioorganic Chemistry
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/152984
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Screening of spiro-substituted thiopyrano[2,3-d]thiazoles for their cytotoxic action on tumor cells / N.I. Zelisko, N.S. Finiuk, V.M. Shvets, Yu.O. Medvid, R.S. Stoika, R.B. Lesyk // Вiopolymers and Cell. — 2017. — Т. 33, № 4. — С. 282-290. — Бібліогр.: 25 назв. — англ.

Aim. To evaluate the in vitro cytotoxicity of novel spiro-substituted thiopyrano[2,3-d]thiazoles towards tumor cells of different tissue origin. Methods. Organic synthesis; spectral methods; MTT test, statistical analysis. Results. In vitro screening of the cytotoxic activity of the 5’-carboxy-7’-ar...