MGMT expression: insights into its regulation. 2. Single nucleotide polymorphisms

• Published in: Вiopolymers and Cell
• Date: 2013
• Main Authors: Iatsyshyna, A.P., Pidpala, O.V., Lukash, L.L.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2013
• Subjects: Reviews
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/153029
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: MGMT expression: insights into its regulation. 2. Single nucleotide polymorphisms / A.P. Iatsyshyna, O.V. Pidpala, L.L. Lukash // Вiopolymers and Cell. — 2013. — Т. 29, №. 5. — С. 367-374. — Бібліогр.: 33 назв. — англ.

High intra- and interindividual variations in the expression levels of the human O6-methylguanine-DNA methyltransferase (MGMT) gene have been observed. This DNA repair enzyme can be a cause of resistance of cancer cells to alkylating chemotherapy. It has been studied the association of single nucleo...