Association of genetic polymorphism with the mutation status of the BRCA1/2 genes in spontanous breast cancer

• Date: 2017
• Main Authors: Polinyk, S.I., Rybchenko, L.A., Klymenko, S.V., Zaharceva, L.M., Klimuk, B.T.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2017
• Series: Вiopolymers and Cell
• Subjects: Biomedicine
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/153097
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Association of genetic polymorphism with the mutation status of the BRCA1/2 genes in spontanous breast cancer / S.I. Polinyk, L.A. Rybchenko, S.V. Klymenko, L.M. Zaharceva, B.T. Klimuk // Вiopolymers and Cell. — 2017. — Т. 33, № 5. — С. 393-400. — Бібліогр.: 29 назв. — англ.

Aim. To study ssociation of the FGFR2 and TOX3/LOC643714 genetic polymorphisms with the BRCA1/2 mutation status in Ukrainian female breast cancer patients without ionizing radiation impact in their histories. Methods. Molecular genetics methods were used. Non-parametric data were evaluated using the two-way Fisher’s Exact test. Statistical analysis was performed using the StatPlus Pro program package. Results. Association of genetic polymorphisms rs2981582 of the FGFR2 gene and rs3803662 of the TOX3/LOC643714 gene with the mutation status of the BRCA1/2 genes in breast cancer patients non-treated with ionizing radiation in their histories was shown. Conclusion. The association between the minor genotype of the TOX3/LOC643714 gene and the positive status of the BRCA1 gene was found to be reliable. No statistic association was found between homozygotes for the major alleles and heterozygote polymorphisms of the FGFR2, TOX3 / LOC643714 genes, with or without BRCA1/2 mutations (p < 0.05).