Correlation of mutagenesis level with expression of reparative enzyme O6-methylguanine DNA methyltransferase during establishment of cell lines in vitro

• Published in: Вiopolymers and Cell
• Date: 2013
• Main Authors: Macewicz, L.L., Kushniruk, V.O., Iatsyshyna, A.P., Kotsarenko, K.V., Lylo, V.V., Akopyan, G.R., Huleuk, N.L., Mykytenko, D.O., Lukash, L.L.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2013
• Subjects: Genomics, Transcriptomics and Proteomics
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/153665
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Correlation of mutagenesis level with expression of reparative enzyme O6-methylguanine DNA methyltransferase during establishment of cell lines in vitro / L.L. Macewicz, V.O. Kushniruk, A.P. Iatsyshyna, K.V. Kotsarenko, V.V. Lylo, G.R. Akopyan, N.L. Huleuk, D.O. Mykytenko, L.L. Lukash // Вiopolymers and Cell. — 2013. — Т. 29, №. 6. — С. 480-486. — Бібліогр.: 24 назв. — англ.

Long-term cultivation of cell lines inevitably leads to genetic and epigenetic changes. The aim of this work was a comparative analysis of karyotype and level of the expression of reparative enzyme O6-methylguanine-DNA- methyltransferase (MGMT) at different stages of establishment and stabilization...