The mechanisms of substrates interaction with the active site of Mycobacterium tuberculosis tyrosyl-tRNA synthetase studied by molecular dynamics simulations

• Published in: Вiopolymers and Cell
• Date: 2014
• Main Authors: Mykuliak, V.V., Kornelyuk, A.I.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2014
• Subjects: Bioinformatics
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/153798
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: The mechanisms of substrates interaction with the active site of Mycobacterium tuberculosis tyrosyl-tRNA synthetase studied by molecular dynamics simulations / V.V. Mykuliak, A.I. Kornelyuk // Вiopolymers and Cell. — 2014. — Т. 30, № 2. — С. 157-162. — Бібліогр.: 39 назв. — англ.

Aim. To study the mechanisms of substrates interaction with the active site of Mycobacterium tuberculosis tyrosyl-tRNA synthetase (MtTyrRS). Methods. Complexes of MtTyrRS with tyrosine, ATP and tyrosyl adenylate were constructed by superposition of the MtTyrRS structure and crystallographic structur...