Structural and functional peculiarities of plasminogen activator inhibitor PAI-1

• Veröffentlicht in: Вiopolymers and Cell
• Datum: 2010
• Hauptverfasser: Zhernossekov, D.D., Zolotareva, E.N., Kondratuk, A.S.
• Format: Artikel
• Sprache: Englisch
• Veröffentlicht: Інститут молекулярної біології і генетики НАН України 2010
• Schlagworte: Reviews
• Online Zugang: https://nasplib.isofts.kiev.ua/handle/123456789/154125
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Zitieren: Structural and functional peculiarities of plasminogen activator inhibitor PAI-1 / D.D. Zhernossekov, E.N. Zolotareva, A.S. Kondratuk // Вiopolymers and Cell. — 2010. — Т. 26, № 4. — С. 255-264. — Бібліогр.: 90 назв. — англ, рос.

PAI-1, an important component of the hemostasis system, is a specific inhibitor of both urokinase type and tissue type plasminogen activators. PAI-1 belongs to the serpin family. The interaction between somatomedin-like domain of vitronectin and PAI-1 leads to stabilization of the latter. PAI-1 late...