Nucleoside N-acylation with active derivatives of amino acids

• Published in: Биополимеры и клетка
• Date: 1996
• Main Authors: Yarmoluk, S.M., Kostenko, A.M., Kryvorotenko, D.V., Dubey, I.Y.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 1996
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/154168
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Nucleoside N-acylation with active derivatives of amino acids / S.M. Yarmoluk, A.M. Kostenko, D.V. Kryvorotenko, I.Y. Dubey // Биополимеры и клетка. — 1996. — Т. 12, № 5. — С. 50-55. — Бібліогр.: 9 назв. — англ.

Simple procedure for N-acylation ofadenosine guanosine and cytidine by active derivatives of amino acids is proposed. Procedure is based on transient silyt protection ofribose hydroxy groups and consists of 3 steps: (a) silytotion of nucleoside by trimethylchloro-silane, (b) reaction of amino group...