DNA recombinant molecules carrying different allels of human preproinsulin gene as mutagens in Chinese hamster cells

• Published in: Биополимеры и клетка
• Date: 1996
• Main Authors: Rubashevsky, E.L., Patskovsky, Y.V., Kirilenko, S.D., Varzanova, I.S., Bogolyubova, O.M., Lysenko, O.F., Lukash, L.L.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 1996
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/154234
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: DNA recombinant molecules carrying different allels of human preproinsulin gene as mutagens in Chinese hamster cells / E.L. Rubashevsky, Y.V. Patskovsky, S.D. Kirilenko, I.S. Varzanova, O.M. Bogolyubova, O.F. Lysenko, L.L. Lukash // Биополимеры и клетка. — 1996. — Т. 12, № 5. — С. 83-92. — Бібліогр.: 30 назв. — англ.

In our earlier investigations it was discovered the nuttagenic activity of two recombinant plasmids (pBR322ins and pAins) containing the human preproinsulin gene in cultivated somatic mammalian cells. The preproinsulin gene (allel-1) was able to function under its own promoter in different cell type...