The mechanisms of activation of the single chain cytokine receptors: preformed and ligand-induced dimerization

• Published in: Вiopolymers and Cell
• Date: 2014
• Main Authors: Gryshkova, V.S., Albu, R.I., Constatinescu, S.N.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2014
• Subjects: Reviews
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/154300
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: The mechanisms of activation of the single chain cytokine receptors: preformed and ligand-induced dimerization / V.S. Gryshkova, R.I. Albu, S.N. Constatinescu // Вiopolymers and Cell. — 2014. — Т. 30, № 3. — С. 184-189. — Бібліогр.: 53 назв. — англ.

Despite intensive studies, the mechanisms of cytokine receptor activation are still not completely understood. Historically two models have been proposed: early studies suggested a mechanism involving ligand-induced di- merization of the receptors which results in the activation of downstream signal...