Application of MALDI-TOF mass spectrometry for study on fibrillar and oligomeric aggregates of alpha-synuclein

• Published in: Вiopolymers and Cell
• Date: 2014
• Main Authors: Severinovskaya, O.V., Kovalska, V.B., Losytskyy, M.Yu., Cherepanov, V.V., Subramaniam, V., Yarmoluk, S.M.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2014
• Subjects: Structure and Function of Biopolymers
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/154302
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Application of MALDI-TOF mass spectrometry for study on fibrillar and oligomeric aggregates of alpha-synuclein / O.V. Severinovskaya, V.B. Kovalska, M.Yu. Losytskyy, V.V. Cherepanov, V. Subramaniam, S.M. Yarmoluk // Вiopolymers and Cell. — 2014. — Т. 30, № 3. — С. 190-196. — Бібліогр.: 26 назв. — англ.

Aim. To study the -synuclein (ASN) aggregates of different structural origin, namely amyloid fibrils and spherical oligomers, in comparison with a native protein. Methods. MALDI TOF mass spectrometry and atomic for- ce microscopy (AFM). Results. The mass spectra of native and fibrillar ASN have simi...