Control of the amount and functionality of the eEF1A1 and eEF1A2 isoforms in mammalian cells

• Published in: Вiopolymers and Cell
• Date: 2018
• Main Authors: Negrutskii, B.S., Novosylna, O.V., Porubleva, L.V., Vislovukh, A.A.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2018
• Subjects: Reviews
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/154368
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Control of the amount and functionality of the eEF1A1 and eEF1A2 isoforms in mammalian cells / B.S. Negrutskii, O.V. Novosylna, L.V. Porubleva, A.A. Vislovukh // Вiopolymers and Cell. — 2018. — Т. 34, № 6. — С. 411-425. — Бібліогр.: 87 назв. — англ.

Aim. To review mechanisms of regulation of expression and the functionality of two isoforms of translation elongation factor eEF1A in mammalian cells. Results. eEF1A1 and eEF1A2 proteins are regulated by post-translational modifications, protein-protein and protein-tRNA interactions as well as by co...