The STAT5 transcription factor in B-cells of patients with chronic lymphocytic leukemia

• Published in: Вiopolymers and Cell
• Date: 2019
• Main Authors: Matvieieva, A.S., Kovalevska, L.M., Ivanivska, T.S., Klein, E., Kashuba, E.V.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2019
• Subjects: Biomedicine
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/154382
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: The STAT5 transcription factor in B-cells of patients with chronic lymphocytic leukemia / A.S. Matvieieva, L.M. Kovalevska, T.S. Ivanivska, E. Klein, E.V. Kashuba // Вiopolymers and Cell. — 2019. — Т. 35, № 1. — С. 30-38. — Бібліогр.: 21 назв. — англ.

Aim. To find out the cause of inhibition of the IL2-STAT5 signaling pathway in chronic lymphocytic leukemia (CLL) cells. Methods.CLL cells were isolated from peripheral blood, using gradient centrifugation on a ficoll-verografin mixture. Expression of the STAT1-6 genes at the mRNA level was analyzed...