Hit identification of FGFR1 inhibitors using receptor-based virtual screening

• Опубліковано в: : Вiopolymers and Cell
• Дата: 2019
• Автори: Tarnavskiy, S.S., Protopopov, M.V., Borovykov, O.V., Pryhodko, A.O., Bdzhola, V.G., Yarmoluk, S.M.
• Формат: Стаття
• Мова: English
• Опубліковано: Інститут молекулярної біології і генетики НАН України 2019
• Теми: Bioorganic Chemistry
• Онлайн доступ: https://nasplib.isofts.kiev.ua/handle/123456789/154388
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Цитувати: Hit identification of FGFR1 inhibitors using receptor-based virtual screening / S.S. Tarnavskiy, M.V. Protopopov, O.V. Borovykov, A.O. Pryhodko, V.G. Bdzhola, S.M. Yarmoluk // Вiopolymers and Cell. — 2019. — Т. 35, № 2. — С. 143-151. — Бібліогр.: 24 назв. — англ.

Aim. To identify novel FGFR1 inhibitors using the virtual screening approach. Methods. Virtual screening of a small organic compounds library was performed by molecular docking using the Autodock 4.2.6 program package. The compounds activity was determined by in vitro biochemical tests using γ-32P A...