Increased antitumor efficiency and reduced negative side effects in laboratory mice of 4-thiazolidinone derivatives in complexes with PEG-containing polymeric nanocarrier

• Published in: Інститут молекулярної біології і генетики НАН України
• Date: 2018
• Main Authors: Kobylinska, L.I., Skorohyd, N.R., Klyuchivska, O.Yu., Mitina, N.E., Zaichenko, A.S., Lesyk, R.B., Zimenkovsky, B.S., Stoika, R.S.
• Format: Article
• Language: English
• Published: 2018
• Subjects: Bioorganic Chemistry
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/154393
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Increased antitumor efficiency and reduced negative side effects in laboratory mice of 4-thiazolidinone derivatives in complexes with PEG-containing polymeric nanocarrier / L.I. Kobylinska, N.R. Skorohyd, O.Yu. Klyuchivska, N.E. Mitina, A.S. Zaichenko, R.B. Lesyk, B.S. Zimenkovsky, R.S. Stoika // Вiopolymers and Cell. — 2018. — Т. 34, № 4. — С. 313-328. — Бібліогр.: 23 назв. — англ.

Aim. To study an anticancer activity and to measure cytological and enzymatic indicators of general toxicity of 4-thiazolidinone-based compounds (Les-3288, Les-3833) in the NK/Ly lymphoma grafted to BALB/C mice. Methods. BALB/C mice were implanted with the ascitic NK/Ly lymphoma and treated for 14 d...