Unrepairable substrates of nucleotide excision repair and their application to suppress the activity of this repair system

• Published in: Вiopolymers and Cell
• Date: 2019
• Main Authors: Popov, A.A., Evdokimov, A.N., Lukyanchikova, N.V., Petruseva, I.O., Lavrik, O.I.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2019
• Subjects: Structure and Function of Biopolymers
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/154395
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Unrepairable substrates of nucleotide excision repair and their application to suppress the activity of this repair system / A.A. Popov, A.N. Evdokimov, N.V. Lukyanchikova, I.O. Petruseva, O.I. Lavrik // Вiopolymers and Cell. — 2019. — Т. 35, № 2. — С. 107-117. — Бібліогр.: 34 назв. — англ.

In the previous studies, the DNA with the bulky Fap-dC derivative was demonstrated to be a difficult substrate for the nucleotide excision repair (NER), a system which is involved in the removal of bulky lesions from DNA. This type of compounds could be of particular interest as possible selective N...