Design of potentially active ligands for SH2 domains by molecular modeling methods

• Published in: Вiopolymers and Cell
• Date: 2014
• Main Authors: Hurmach, V.V., Balinskyi, O.M., Platonov, M.O., Boyko, O.M., Borysko, P.O., Prylutskyy, Yu.I.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2014
• Subjects: Bioinformatics
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/154423
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Design of potentially active ligands for SH2 domains by molecular modeling methods / V.V. Hurmach, O.M. Balinskyi, M.O. Platonov, O.M. Boyko, P.O. Borysko, Yu.I. Prylutskyy // Вiopolymers and Cell. — 2014. — Т. 30, № 4. — С. 321-325. — Бібліогр.: 12 назв. — англ.

Search for new chemical structures possessing specific biological activity is a complex problem that needs the use of the latest achievements of molecular modeling technologies. It is well known that SH2 domains play a major role in ontogenesis as intermediaries of specific protein-protein interacti...