Treatment of lymphoid cells with the topoisomerase II poison etoposide leads to an increased juxtaposition of AML1 and ETO genes on the surface of nucleoli

• Date: 2011
• Main Authors: Rubtsov, M.A., Glukhov, S.I., Allinne, J., Pichugin, A., Vassetzky, Y.S., Razin, S.V., Iarovaia, O.V.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2011
• Series: Вiopolymers and Cell
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/155653
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Treatment of lymphoid cells with the topoisomerase II poison etoposide leads to an increased juxtaposition of AML1 and ETO genes on the surface of nucleoli / M.A. Rubtsov, S.I. Glukhov, J. Allinne, A. Pichugin, Y.S. Vassetzky, S.V. Razin, O.V. Iarovaia // Вiopolymers and Cell. — 2011. — Т. 27, № 5. — С. 398-403. — Бібліогр.: 24 назв. — англ.

AML1 and ETO genes are known partners in the t(8,21) translocation associated with the treatment-related leukaemias in the patients receiving chemotherapy with DNA-topoisomerase II (topo II) poisons. Aim. To determine whether the genes AML1 and ETO are in close proximity either permanently or temp...