Investigation of DNA topoisomerase I as an autoantigen at the thyroid cancer

• Published in: Біополімери і клітина
• Date: 2001
• Main Authors: Sidorik, L.L., Rybkinska, T.A., Vigontina, O.G., Vudmaska, M.I., Naidenov, V.G., Pogribnyi, P.V., Lisovskii, I.L., Schvachko, L.P., Bronstein, I., Lyzogubov, V.V., Prihod`ko, E.A., Usenko, V.S., Matsuka, G.Kh.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2001
• Subjects: Біомедицина
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/155894
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Investigation of DNA topoisomerase I as an autoantigen at the thyroid cancer / L.L. Sidorik, T.A. Rybkinska, O.G. Vigontina, M.I. Vudmaska, V.G. Naidenov, P.V. Pogribnyi, I.L. Lisovskii, L.P. Schavachko, I. Bronstein, V.V. Lyzogubov, E.A. Prihod`ko, V.S. Usenko, G.Kh. Matsuka // Біополімери і клітина. — 2001. — Т. 17, № 6. — С. 551-555. — Бібліогр.: 20 назв. — англ.

The data concerning DNA-Topoisomerase I (Topo-I) from human placenta as an autoantigen at the thyroid cancer are presented. A new effective scheme of the Topo-I purification using the High-Trap columns is described, as well as the enzyme physico-chemical properties and its immunoreactivity in the EL...