Signaling pathways involved in apoptosis induced by novel angucycline antibiotic landomycin E in Jurkat T-leukemia cells

• Published in: Вiopolymers and Cell
• Date: 2011
• Main Author: Panchuk, R.R.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2011
• Subjects: Structure and Function of Biopolymers
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/156386
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Signaling pathways involved in apoptosis induced by novel angucycline antibiotic landomycin E in Jurkat T-leukemia cells / R.R. Panchuk // Вiopolymers and Cell. — 2011. — Т. 27, № 2. — С. 124-131. — Бібліогр.: 26 назв. — англ.

Aim. To study the molecular mechanisms of action of novel anticancer antibiotic landomycin E (LE). Methods. Annexin V/propidium iodide, DAPI (4',6-diamidino-2-phenylindole) staining, Western-blot analysis.
 Results. LE applied in 2 µg/ml dose (IC50), induced reactive oxygen species (ROS...