High selectivity of mutagenic action of synthetic polynucleotides

• Published in: Биополимеры и клетка
• Date: 1999
• Main Author: Alexandrov, Yu.N.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 1999
• Subjects: Обзоры
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/156535
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: High selectivity of mutagenic action of synthetic polynucleotides / Yu.N. Alexandrov // Биополимеры и клетка. — 1999. — Т. 15, № 4. — С. 257-261. — Бібліогр.: 19 назв. — англ.

Solutions of high molecular weight syntetic poiyribo- and polydeoxyribonucleotides of known chemical structure injected into Drosophila melanogaster males caused a 6–17 fold increase of the overall frequency of the recessive lethals in the 2nd chromosome. Complementation analysis of the induced leth...