Gene targeting in melanoma therapy: exploiting of surface markers and specific promoters

• Published in: Вiopolymers and Cell
• Date: 2012
• Main Authors: Alekseenko, I.V., Zinovyeva, M.V., Pleshkan, V.V., Sverdlov, E.D.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2012
• Subjects: Reviews
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/156706
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Gene targeting in melanoma therapy: exploiting of surface markers and specific promoters / I.V. Alekseenko, M.V. Zinovyeva, V.V. Pleshkan, E.D. Sverdlov // Вiopolymers and Cell. — 2012. — Т. 28, № 1. — С. 3-13. — Бібліогр.: 84 назв. — англ., рос.

One of the problems of gene therapy of melanoma is effective expression of therapeutic gene in tumor cells and their metastases but not in normal cells. In this review, we will consider a two-step approach to a highly specific gene therapy. At the first step, therapeutic genes are delivered specific...