Current approaches to improve the anticancer chemotherapy with alkylating agents: state of the problem in world and Ukraine

• Published in: Вiopolymers and Cell
• Date: 2012
• Main Author: Iatsyshyna, A.P.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2012
• Subjects: Reviews
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/156760
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Current approaches to improve the anticancer chemotherapy with alkylating agents: state of the problem in world and Ukraine / A.P. Iatsyshyna // Вiopolymers and Cell. — 2012. — Т. 28, № 2. — С. 83-92. — Бібліогр.: 58 назв. — англ.

Alkylating agents are frequently used in many established anticancer chemotherapies. They alkylate the genomic DNA at various sites. Alkylation of the guanine at the O6-position is cytotoxic, it has the strongest mutagenic potential, as well as can cause the tumor development. Alkyl groups at the O6...