The new base excision repair pathway in mammals mediated by tyrosyl-DNA-phosphodiesterase 1

• Veröffentlicht in: Вiopolymers and Cell
• Datum: 2012
• Hauptverfasser: Lebedeva, N.A., Rechkunova, N.I., Lavrik, O.I.
• Format: Artikel
• Sprache: Englisch
• Veröffentlicht: Інститут молекулярної біології і генетики НАН України 2012
• Schlagworte: Minireviews
• Online Zugang: https://nasplib.isofts.kiev.ua/handle/123456789/156841
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Zitieren: The new base excision repair pathway in mammals mediated by tyrosyl-DNA-phosphodiesterase 1 / N.A. Lebedeva, N.I. Rechkunova, O.I. Lavrik // Вiopolymers and Cell. — 2012. — Т. 28, № 3. — С. 202-206. — Бібліогр.: 36 назв. — англ.

Human tyrosyl-DNA phosphodiesterase 1 (Tdp1) hydrolyzesthe phosphodiester bond at a DNA 3' end linked to a tyrosyl moiety and has been implicated in the repair of Topoisomerase I (TopI )-DNA covalent complexes. Tdp1 can also hydrolyze other 3' end DNA alterations including 3' phosphog...