Synthesis and evaluation of antitumor activity of some thiazolo[4,5-b]pyridines

• Date: 2012
• Main Authors: Chaban, T.I., Panchuk, R.R., Klenina, O.V., Skorokhyd, N.R., Ogurtsov, V.V., Chaban, I.G.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2012
• Series: Вiopolymers and Cell
• Subjects: Bioorganic Chemistry
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/156904
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Synthesis and evaluation of antitumor activity of some thiazolo[4,5-b]pyridines / T.I. Chaban, R.R. Panchuk, O.V. Klenina, N.R. Skorokhyd, V.V. Ogurtsov, I.G. Chaban // Вiopolymers and Cell. — 2012. — Т. 28, № 5. — С. 389-396. — Бібліогр.: 18 назв. — англ.

Aim. To synthesize a series of novel 3H-thiazolo[4,5-b]pyridine-2-ones by structural modification of the core heterocycle in its N3- and N6-positions and to evaluate their anticancer activity in vitro on several tumor cell lines. Methods. Organic synthesis, 1 H-NMR spectroscopy, trypan blue cell v...