Геном эукариотов: на пути прочтения от альфы до омеги
Рецензия на книгу Т. Ю. Колотовой, Б. Т. Стегния, И. Ю. Кучмы 
 Н. В, Дубининой, А. Н. Головко, Ю. Б. Чайковского и Ю. Л. Волянского 
 «Механизмы и контроль перестроек генома эукариот» 
 (Харьков: «Коллегиум», 2004.—263 с.) Рецензія на книгу Т. Ю. Колотова, Б. Т. Стегнія, І....
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Інститут молекулярної біології і генетики НАН України
2007
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| Cite this: | Геном эукариотов: на пути прочтения от альфы до омеги / Е.И. Черепенко, Д.Н. Говорун // Біополімери і клітина. — 2007. — Т. 23, № 1. — С. 60-62. — Бібліогр.: 3 назв. — рос., англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1860269261384056832 |
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| author | Черепенко, Е.И. Говорун, Д.Н. |
| author_facet | Черепенко, Е.И. Говорун, Д.Н. |
| citation_txt | Геном эукариотов: на пути прочтения от альфы до омеги / Е.И. Черепенко, Д.Н. Говорун // Біополімери і клітина. — 2007. — Т. 23, № 1. — С. 60-62. — Бібліогр.: 3 назв. — рос., англ. |
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| description | Рецензия на книгу Т. Ю. Колотовой, Б. Т. Стегния, И. Ю. Кучмы 
Н. В, Дубининой, А. Н. Головко, Ю. Б. Чайковского и Ю. Л. Волянского 
«Механизмы и контроль перестроек генома эукариот» 
(Харьков: «Коллегиум», 2004.—263 с.)
Рецензія на книгу Т. Ю. Колотова, Б. Т. Стегнія, І. Ю. Кучми Н. В, Дубініною, А. Н. Головко, Ю. Б. Чайковського і Ю. Л. Волянського «Механізми і контроль перебудов геному еукаріот» (Харків:. «Колегіум», 2004.-263 с)
Review of the book: “Mechanisms and control of eukaryotic genome rearrangements” written by T. U. Kolotova, B. T. Stegnii, I. U. Kouchma, N. V. Dubinina, A. N. Golovko, U. B. Chaikovski and U. L. Volyanski, Kharkov, Collegium Press, 2004, 263 p.
|
| first_indexed | 2025-12-07T19:05:00Z |
| format | Article |
| fulltext |
Ge nome of eukaryotes:
on ef forts to read it from a to w
(Re view of the book: “Mech a nisms and con trol of eukaryotic ge nome re ar range -
ments” writ ten by T.U. Kolotova, B.T. Stegnii, I.U. Kouchma, N.V. Dubinina, A.N.
Golovko, U.B. Chaikovski and U.L. Volyanski, Kharkov, Collegium Press, 2004,
263 p.)
In 1984 two pub li ca tions at tracted at ten tion of ge net i -
cists in Sla vonic coun tries. One of them was that of B.
McClintock who pub lished in Sci ence her No bel
speech ded i cated to the dis cov ery of mo bile el e ments
[1]. The other one was a book writ ten by Mos cow pro -
fes sor R.V. Khesin who sum ma rized mul ti tu di nous re -
sults that could be united un der the ti tle “Ge nome mo -
bil ity” [2]. These pub li ca tions marked the point of a
shift in ge nome re search par a digm from treat ing ge -
nome as a static struc ture con tain ing genes like beads in
a neck lace (ini tially stud ied also as sep a rate units in
frame of «one gene one en zyme» con cep tion) to a
highly dy namic or ga ni za tion. The lat ter obeys some
spe cial laws gov ern ing the ge nome sta tus de pend ing on
cell re quire ments and en vi ron men tal con di tions. The
ge nome dy namic prop er ties are en dowed with a host of
bi o log i cal func tions in clud ing ho meo sta sis main tain -
ing, ge netic dis eases, in clud ing ma lig nan cies emer -
gence, and fi nally spe cies for ma tion and evo lu tion.
20 years later, at the heart of post-genomic era deal -
ing with the knowl edge of full ge netic text of many or -
gan isms that could be re ferred to as an a let ter in ge -
nome de ci pher ing this book ap peared in Kharkov,
Ukraine. Writ ten co op er a tively by many spe cial ists it is
a timely sur vey of re sults on the way of study ing the al -
pha bite of the ge nome as Book of Life.
As the fol low ing b let ter of genomic al pha bite the
reader could in ter pret the de scribed abil ity of ge nome
to dy namic re or ga ni za tion of the struc ture ini tially con -
sid ered as canonic. When, why and how do these
or ga ni za tions oc cur? What af ter ef fects of such re or ga -
ni za tions fol low? If some spe cial code to do it ex ists
then what el e ments of this code might be? Study ing the
pos si bil ity to an swer these ques tions was a mo tive force
for the au thors to com pose this book.
Dif fer ent po si tions at the ge nome of the mo bile el e -
ment re sult in dif fer ent phe no types and, there fore, the
ge nome cod ing ca pac ity de pends on not only the size of
cod ing se quences but also com bi na tions of ge nome dif -
fer ent parts in side the nu cleus. Not only mo bile el e -
ments at tracted much at ten tion but also dif fer ent cis-
and trans-fac tors in volved into site-spe cific pro cesses
of genomic level, in clud ing mech a nisms of these fac -
tors ac ti va tion, their abil ity to form com plexes and re -
cruit only spe cial fac tors ac tive with these el e ments as
well as their role in si lenc ing the ap pro pri ate genes.
This shows that the abil ity of ge nome to re or ga nize it -
self must be pro grammed. That this is the fact, the first
chap ter of the book dem on strates in de tails of im mune
re sponse as a re sult of the right cis- and trans-el e ments
ac ti va tion at the right time and at the right place.
Hypermutability in her ent to this type of re ar range -
ments el e vates the level of an out put prod uct (an ti bod -
ies) di ver si fi ca tion that al low better to choose vari ant
re quired for the case.
The sec ond ex am ple dem on strat ing the role of a
wider range of phe no types for the se lec tion of the most
suit able one among them is the mei otic re com bi na tion.
60
ISSN 0233-7657. Biopolymers and cell. 2007. Vol. 23. ISS 1. Translated from Ukrainia.
© CHEREPENKO E. I., HOVORUN D. M, 2007
BOOK REVIEW
It is de scribed in the sec ond chap ter. It was shown that
in yeast the mei otic re com bi na tion is de vel oped as a
stress re ac tion of the ge nome that could sur vive due to
the pos si bil ity of ap pear ance of the fit ted phe no type.
Struc tural and func tional pe cu liar i ties of this pro cess in
yeast and other higher or gan isms are char ac ter ized.
The pro grammed ge nome re ar range ments meet the
re quire ments not only to be highly di verse but also ef -
fec tively used dur ing the life span. About 10 mil lions of
spe cies com prise our eco sys tem and among them there
is one very sim ple or gan ism called ‘cil i ates’. The main
fea ture of their ge nome is la bor di vi sion be tween
macro- and micronucleus. This is jus ti fied be cause cil i -
ates can mul ti ply them selves both asex u ally and sex u -
ally. In the first case no sex de ter mi nants are nec es sary
and ge nome of the macronucleus is pro cessed in such a
man ner that not needed ge netic ma te rial is dis carded
due to spe cific re ac tions. This model is de scribed in de -
tails in the book as the best to study the pro cess of
chromatin dim i nu tion where it can oc cur.
How can ge nome sense the threat en ing sit u a tion
and pre pare to face it us ing its po ten tial for re ar range -
ments? In her No bel speech B. McClintock said, «We
know noth ing, how ever, about how the cell senses dan -
ger and in sti gates re sponses to it that of ten are truly re -
mark able». 20 years later the au thors of the re viewed
book showed that ge nome can sense dan ger due to al -
ter ations in pat tern of spe cific epigenetic mod i fi ca tions
re sult ing from en vi ron men tal and en dog e nous con di -
tions. This, cur rently es pe cially in tense, field of re -
searches might be des ig nated as g let ter of ge nome al -
pha bite ac cord ing to the used cliché. Data on both
DNA and histone code el e ments mod i fi ca tions are sum -
ma rized in the book, the mech a nisms of mod i fi ca tion
emerg ing and eras ing as well as the mech a nisms of pos -
si ble epigenetic in her i tance are dis cussed.
The book shows that ge nome re ar range ment is a
pro grammed pro cess. Could re ar range ments hap pen as
a non-pro grammed event? The data an a lyzed in the
book al low an swer ing pos i tively. First, the pro -
grammed pro cesses could some times loose the con trol
and en ter the wrong way of fulfillments. Sec ond, ge -
nome could face any en vi ron men tal or en dog e nous as -
sault us ing the in her ent mech a nisms of ge netic plas tic -
ity. Spe cial chap ter of the book shows that these mech a -
nisms are ex actly the same as those for the pro grammed
events. (Sur pris ingly, this ge nome be hav ior re sem bles
that of the whole stressed or gan ism chang ing the pat -
tern of ac tiv ity of dif fer ent phys i o log i cal sys tems and
de vel op ing gen eral adap tive syn drome de scribed by
Hans Selye). The book al lows rais ing a ques tion if
mam mal liver re gen er a tion is also ac com pa nied by ge -
nome re ar range ments.
The book cov ers the vast ma jor ity of ex per i men tal
data ob tained us ing yeast, drosophila, plants, cil i ates,
and mam mals. In rather short writ ing the reader (even a
stu dent) is tac itly taken as fa mil iar with the main pe cu -
liar i ties of these mod els. Oth er wise, no de tails in many
cases an a lyzed (e.g. why and how an ti bod ies are di -
vided into classes) make the book dif fi cult to ab sorb.
The same ef fect is pro duced be cause no list of ab bre vi a -
tions (that are in fact the sec ond lan guage of the book)
is sup plied. More over, it is not al ways clear what the
ab bre vi a tions used stand for. There are some tech ni cal
er rors in spell ing, leg end ex pla na tion (Fig.VIII with
P-nu cle o tide mean ing omit ted) as well as in ef fi ciency
of find ing many good points of the book be cause no in -
dex of ma te rial an a lyzed is used at all. This, how ever,
does not lower much the value of the book.
Be sides the anal y sis of data ob tained the book in sti -
gates rais ing novel ques tions in study ing the al pha bite
of ge nome. One of them con cerns the ap pear ance of
mu ta tions ac com pa ny ing the pro cess of re ar range -
ments. The known «mutagenases», ter mi nal and
translesion polymerases may not ex haust cell po ten tial
to al ter ation. Ca pac ity of DNA bases to form tautomers
due to pro ton abil ity to mi grate from one to an other
atom in side the mol e cule and be ing es pe cially ac tive
un der stress con di tions could come into op er a tion as a
source of mu ta tion emer gence.
Also, study of ge netic plas tic ity in prokaryotes
could open novel in sights on the study of ge nome al pha
bite. In prokaryotes the phe nom e non of pro tein splic ing
is wide spread. On the one hand, inteins with their prop -
er ties of ge nome hom ing could be an el e ment im por tant
for ge nome re ar range ments. On the other hand, if
inteins could turn out to be those pro teins that are ca pa -
ble of pro tect ing tar gets from le thal lig ands (an ti bi ot -
ics) [3] they could be long to the cell sens ing ma chin ery
and par tic i pate in in duc tion of ge nome re or ga ni za tion,
in case of eukaryotes in some spe cific way.
61
Cherepenko E. I., Hovorun D. M.
No doubt the book is a con spic u ous event in ge net -
ics in our coun try and can be en thu si as ti cally rec om -
mended for many spe cial ists and stu dents.
REFERENCES:
1. McClintock B/ The Sig nif i cance of Re sponses of the Ge nome to
Chal lenge // Sci ence, 1984. 226, 792-801.
2. Khesin R.V. Ge nome Mo bil ity// 1984, “Nauka” Press,Mos cow 472 p.
3. Sidorenko S.V.andV.I.Tishkov. Mo lec u lar ba sis of re sis tance to an ti -
bi ot ics. // Uspechi biol. khimii , 2004.v.44.p.263-306 .
Yelena Cherepenko
Dmytro Hovorun.
In sti tute of Mo lec u lar Bi ol ogy and Ge net ics
Na tional Acad emy of Sci ences of Ukraine,
Kyiv
62
Ge nome of eukaryotes
|
| id | nasplib_isofts_kiev_ua-123456789-156913 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 0233-7657 |
| language | Russian |
| last_indexed | 2025-12-07T19:05:00Z |
| publishDate | 2007 |
| publisher | Інститут молекулярної біології і генетики НАН України |
| record_format | dspace |
| spelling | Черепенко, Е.И. Говорун, Д.Н. 2019-06-19T09:10:59Z 2019-06-19T09:10:59Z 2007 Геном эукариотов: на пути прочтения от альфы до омеги / Е.И. Черепенко, Д.Н. Говорун // Біополімери і клітина. — 2007. — Т. 23, № 1. — С. 60-62. — Бібліогр.: 3 назв. — рос., англ. 0233-7657 https://nasplib.isofts.kiev.ua/handle/123456789/156913 Рецензия на книгу Т. Ю. Колотовой, Б. Т. Стегния, И. Ю. Кучмы 
 Н. В, Дубининой, А. Н. Головко, Ю. Б. Чайковского и Ю. Л. Волянского 
 «Механизмы и контроль перестроек генома эукариот» 
 (Харьков: «Коллегиум», 2004.—263 с.) Рецензія на книгу Т. Ю. Колотова, Б. Т. Стегнія, І. Ю. Кучми Н. В, Дубініною, А. Н. Головко, Ю. Б. Чайковського і Ю. Л. Волянського «Механізми і контроль перебудов геному еукаріот» (Харків:. «Колегіум», 2004.-263 с) Review of the book: “Mechanisms and control of eukaryotic genome rearrangements” written by T. U. Kolotova, B. T. Stegnii, I. U. Kouchma, N. V. Dubinina, A. N. Golovko, U. B. Chaikovski and U. L. Volyanski, Kharkov, Collegium Press, 2004, 263 p. ru Інститут молекулярної біології і генетики НАН України Біополімери і клітина Рецензії Геном эукариотов: на пути прочтения от альфы до омеги Genome of eukaryotes: on efforts to read it from α to ω Геном еукаріотів: на шляху прочитання від альфи до омеги Article published earlier |
| spellingShingle | Геном эукариотов: на пути прочтения от альфы до омеги Черепенко, Е.И. Говорун, Д.Н. Рецензії |
| title | Геном эукариотов: на пути прочтения от альфы до омеги |
| title_alt | Genome of eukaryotes: on efforts to read it from α to ω Геном еукаріотів: на шляху прочитання від альфи до омеги |
| title_full | Геном эукариотов: на пути прочтения от альфы до омеги |
| title_fullStr | Геном эукариотов: на пути прочтения от альфы до омеги |
| title_full_unstemmed | Геном эукариотов: на пути прочтения от альфы до омеги |
| title_short | Геном эукариотов: на пути прочтения от альфы до омеги |
| title_sort | геном эукариотов: на пути прочтения от альфы до омеги |
| topic | Рецензії |
| topic_facet | Рецензії |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/156913 |
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