Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances

Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances

Model phospholipid membranes are considered as sensor bionanomaterials to characterize water-soluble drugs of kosmotropic and chaotropic nature. Effects of kosmotropic agent dimethylsulfoxide (DMSO) and chaotropic tilorone on 1,2-dipalmitoylphosphatidylchoine multibilayer membranes were studied by d...

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Published in:Functional Materials
Date:2018
Main Authors: Vashchenko, O.V., Kasian, N.A., Brodskii, R.Ye., Budianska, L.V., Sofronov, D.S., Lisetski, L.N.
Format: Article
Language:English
Published: НТК «Інститут монокристалів» НАН України 2018
Subjects:
Characterization and properties
Online Access:https://nasplib.isofts.kiev.ua/handle/123456789/157157
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Journal Title:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Cite this:Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances / O.V. Vashchenko, N.A. Kasian, R.Ye. Brodskii, L.V. Budianska, D.S. Sofronov, L.N. Lisetski // Functional Materials. — 2018. — Т. 25, № 3. — С. 422-431. — Бібліогр.: 58 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-157157
record_format dspace
spelling Vashchenko, O.V.
Kasian, N.A.
Brodskii, R.Ye.
Budianska, L.V.
Sofronov, D.S.
Lisetski, L.N.
2019-06-19T16:33:08Z
2019-06-19T16:33:08Z
2018
Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances / O.V. Vashchenko, N.A. Kasian, R.Ye. Brodskii, L.V. Budianska, D.S. Sofronov, L.N. Lisetski // Functional Materials. — 2018. — Т. 25, № 3. — С. 422-431. — Бібліогр.: 58 назв. — англ.
1027-5495
DOI:https://doi.org/10.15407/fm25.03.422
https://nasplib.isofts.kiev.ua/handle/123456789/157157
Model phospholipid membranes are considered as sensor bionanomaterials to characterize water-soluble drugs of kosmotropic and chaotropic nature. Effects of kosmotropic agent dimethylsulfoxide (DMSO) and chaotropic tilorone on 1,2-dipalmitoylphosphatidylchoine multibilayer membranes were studied by differential scanning calorimetry and Fourier-transformed infrared spectroscopy. Tilorone and DMSO, water soluble hydrophilic substances, induced opposite shifts of membrane main phase transition temperatures ΔT, which were positive for DMSO (as a kosmotropic dopant) and negative for chaotropic tilorone. For both dopants, dependences of ΔT vs. dopant concentration c were obtained and fitted by an analogue of the Freundlich equation of adsorption, ΔT = kc¹/n. A model has been proposed describing the action of hydrophilic dopants on lipid bilayer in terms of additional lateral pressure P(c), which is positive for kosmotropes and negative for chaotropes. Applying the Clapeyron-Clausius equation to establish the character of ΔT(c) relation, power-law dependence was obtained, which was in good agreement with our exrimental data. From comparison with literature data on Langmuir monolayers of similar systems, it was noted that the same power law relations could describe both phase transition temperature shifts and pressure-area dependences as function of dopant concentration.
en
НТК «Інститут монокристалів» НАН України
Functional Materials
Characterization and properties
Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances
spellingShingle Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances
Vashchenko, O.V.
Kasian, N.A.
Brodskii, R.Ye.
Budianska, L.V.
Sofronov, D.S.
Lisetski, L.N.
Characterization and properties
title_short Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances
title_full Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances
title_fullStr Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances
title_full_unstemmed Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances
title_sort model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances
author Vashchenko, O.V.
Kasian, N.A.
Brodskii, R.Ye.
Budianska, L.V.
Sofronov, D.S.
Lisetski, L.N.
author_facet Vashchenko, O.V.
Kasian, N.A.
Brodskii, R.Ye.
Budianska, L.V.
Sofronov, D.S.
Lisetski, L.N.
topic Characterization and properties
topic_facet Characterization and properties
publishDate 2018
language English
container_title Functional Materials
publisher НТК «Інститут монокристалів» НАН України
format Article
description Model phospholipid membranes are considered as sensor bionanomaterials to characterize water-soluble drugs of kosmotropic and chaotropic nature. Effects of kosmotropic agent dimethylsulfoxide (DMSO) and chaotropic tilorone on 1,2-dipalmitoylphosphatidylchoine multibilayer membranes were studied by differential scanning calorimetry and Fourier-transformed infrared spectroscopy. Tilorone and DMSO, water soluble hydrophilic substances, induced opposite shifts of membrane main phase transition temperatures ΔT, which were positive for DMSO (as a kosmotropic dopant) and negative for chaotropic tilorone. For both dopants, dependences of ΔT vs. dopant concentration c were obtained and fitted by an analogue of the Freundlich equation of adsorption, ΔT = kc¹/n. A model has been proposed describing the action of hydrophilic dopants on lipid bilayer in terms of additional lateral pressure P(c), which is positive for kosmotropes and negative for chaotropes. Applying the Clapeyron-Clausius equation to establish the character of ΔT(c) relation, power-law dependence was obtained, which was in good agreement with our exrimental data. From comparison with literature data on Langmuir monolayers of similar systems, it was noted that the same power law relations could describe both phase transition temperature shifts and pressure-area dependences as function of dopant concentration.
issn 1027-5495
url https://nasplib.isofts.kiev.ua/handle/123456789/157157
citation_txt Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances / O.V. Vashchenko, N.A. Kasian, R.Ye. Brodskii, L.V. Budianska, D.S. Sofronov, L.N. Lisetski // Functional Materials. — 2018. — Т. 25, № 3. — С. 422-431. — Бібліогр.: 58 назв. — англ.
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first_indexed 2025-12-07T17:12:10Z
last_indexed 2025-12-07T17:12:10Z
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