Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances
Model phospholipid membranes are considered as sensor bionanomaterials to characterize water-soluble drugs of kosmotropic and chaotropic nature. Effects of kosmotropic agent dimethylsulfoxide (DMSO) and chaotropic tilorone on 1,2-dipalmitoylphosphatidylchoine multibilayer membranes were studied by d...
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| Опубліковано в: : | Functional Materials |
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| Дата: | 2018 |
| Автори: | , , , , , |
| Формат: | Стаття |
| Мова: | Англійська |
| Опубліковано: |
НТК «Інститут монокристалів» НАН України
2018
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| Теми: | |
| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/157157 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances / O.V. Vashchenko, N.A. Kasian, R.Ye. Brodskii, L.V. Budianska, D.S. Sofronov, L.N. Lisetski // Functional Materials. — 2018. — Т. 25, № 3. — С. 422-431. — Бібліогр.: 58 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862708678590726144 |
|---|---|
| author | Vashchenko, O.V. Kasian, N.A. Brodskii, R.Ye. Budianska, L.V. Sofronov, D.S. Lisetski, L.N. |
| author_facet | Vashchenko, O.V. Kasian, N.A. Brodskii, R.Ye. Budianska, L.V. Sofronov, D.S. Lisetski, L.N. |
| citation_txt | Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances / O.V. Vashchenko, N.A. Kasian, R.Ye. Brodskii, L.V. Budianska, D.S. Sofronov, L.N. Lisetski // Functional Materials. — 2018. — Т. 25, № 3. — С. 422-431. — Бібліогр.: 58 назв. — англ. |
| collection | DSpace DC |
| container_title | Functional Materials |
| description | Model phospholipid membranes are considered as sensor bionanomaterials to characterize water-soluble drugs of kosmotropic and chaotropic nature. Effects of kosmotropic agent dimethylsulfoxide (DMSO) and chaotropic tilorone on 1,2-dipalmitoylphosphatidylchoine multibilayer membranes were studied by differential scanning calorimetry and Fourier-transformed infrared spectroscopy. Tilorone and DMSO, water soluble hydrophilic substances, induced opposite shifts of membrane main phase transition temperatures ΔT, which were positive for DMSO (as a kosmotropic dopant) and negative for chaotropic tilorone. For both dopants, dependences of ΔT vs. dopant concentration c were obtained and fitted by an analogue of the Freundlich equation of adsorption, ΔT = kc¹/n. A model has been proposed describing the action of hydrophilic dopants on lipid bilayer in terms of additional lateral pressure P(c), which is positive for kosmotropes and negative for chaotropes. Applying the Clapeyron-Clausius equation to establish the character of ΔT(c) relation, power-law dependence was obtained, which was in good agreement with our exrimental data. From comparison with literature data on Langmuir monolayers of similar systems, it was noted that the same power law relations could describe both phase transition temperature shifts and pressure-area dependences as function of dopant concentration.
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| first_indexed | 2025-12-07T17:12:10Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-157157 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1027-5495 |
| language | English |
| last_indexed | 2025-12-07T17:12:10Z |
| publishDate | 2018 |
| publisher | НТК «Інститут монокристалів» НАН України |
| record_format | dspace |
| spelling | Vashchenko, O.V. Kasian, N.A. Brodskii, R.Ye. Budianska, L.V. Sofronov, D.S. Lisetski, L.N. 2019-06-19T16:33:08Z 2019-06-19T16:33:08Z 2018 Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances / O.V. Vashchenko, N.A. Kasian, R.Ye. Brodskii, L.V. Budianska, D.S. Sofronov, L.N. Lisetski // Functional Materials. — 2018. — Т. 25, № 3. — С. 422-431. — Бібліогр.: 58 назв. — англ. 1027-5495 DOI:https://doi.org/10.15407/fm25.03.422 https://nasplib.isofts.kiev.ua/handle/123456789/157157 Model phospholipid membranes are considered as sensor bionanomaterials to characterize water-soluble drugs of kosmotropic and chaotropic nature. Effects of kosmotropic agent dimethylsulfoxide (DMSO) and chaotropic tilorone on 1,2-dipalmitoylphosphatidylchoine multibilayer membranes were studied by differential scanning calorimetry and Fourier-transformed infrared spectroscopy. Tilorone and DMSO, water soluble hydrophilic substances, induced opposite shifts of membrane main phase transition temperatures ΔT, which were positive for DMSO (as a kosmotropic dopant) and negative for chaotropic tilorone. For both dopants, dependences of ΔT vs. dopant concentration c were obtained and fitted by an analogue of the Freundlich equation of adsorption, ΔT = kc¹/n. A model has been proposed describing the action of hydrophilic dopants on lipid bilayer in terms of additional lateral pressure P(c), which is positive for kosmotropes and negative for chaotropes. Applying the Clapeyron-Clausius equation to establish the character of ΔT(c) relation, power-law dependence was obtained, which was in good agreement with our exrimental data. From comparison with literature data on Langmuir monolayers of similar systems, it was noted that the same power law relations could describe both phase transition temperature shifts and pressure-area dependences as function of dopant concentration. en НТК «Інститут монокристалів» НАН України Functional Materials Characterization and properties Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances Article published earlier |
| spellingShingle | Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances Vashchenko, O.V. Kasian, N.A. Brodskii, R.Ye. Budianska, L.V. Sofronov, D.S. Lisetski, L.N. Characterization and properties |
| title | Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances |
| title_full | Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances |
| title_fullStr | Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances |
| title_full_unstemmed | Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances |
| title_short | Model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances |
| title_sort | model lipid bilayers as sensor bionanomaterials for characterization of membranotropic action of water-soluble substances |
| topic | Characterization and properties |
| topic_facet | Characterization and properties |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/157157 |
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