Cover Image

Antiproliferative activities of some 7-hydroxy-3-aryloxy-2-trifluoromethyl-4H-4-chromenone derivatives against 60 human cancer cell lines

234 derivatives of 7-hydroxy-3-aryloxy-2-trifluoromethyl-4H-4-chromenones were synthesized and tested for antitumor activity in vitro against human cancer cell lines in NCI (National Cancer Institute, USA) bioassay. It was shown high cytostatic and cytotoxic activity for the tested compounds 1-8 (GI...

Full description

Saved in:

Bibliographic Details
Published in:	Біополімери і клітина
Date:	2004
Main Authors:	Prykhod'ko, A.O., Dubinina, G.G., Khilya, V.P., Yarmoluk, S.M.
Format:	Article
Language:	Ukrainian
Published:	Інститут молекулярної біології і генетики НАН України 2004
Subjects:	Ювілеї
Online Access:	https://nasplib.isofts.kiev.ua/handle/123456789/157205
Tags:	Add Tag No Tags, Be the first to tag this record!
Journal Title:	Digital Library of Periodicals of National Academy of Sciences of Ukraine
Cite this:	Antiproliferative activities of some 7-hydroxy-3-aryloxy-2-trifluoromethyl-4H-4-chromenone derivatives against 60 human cancer cell lines / A.O. Prykhod'ko, G.G. Dubinina, V.P. Khilya, S.M. Yarmoluk// Біополімери і клітина. — 2004. — Т. 20, № 1-2. — С. 159-163. — Бібліогр.: 24 назв. — англ.

Institution

Digital Library of Periodicals of National Academy of Sciences of Ukraine

Similar Items

Evaluation of 4H-4-chromenone derivatives as inhibitors of protein kinase CK2
by: Prykhodko, A.O., et al.
Published: (2005)

Synthesis and the biological activity of 4-hydroxy-2,2-dioxo-1H-2λ6,1-benzothiazin-3-carboxylic acids trifluoromethyl-substituted anilides
by: L. A. Petrushova, et al.
Published: (2015)

Trifluoromethyl-containing 3,4-dihydropyrimidine-2-ones and their condensed analogs
by: S. V. Melnykov, et al.
Published: (2018)

Synthesis of 4,4-bis(nonafluorobiphenyl-4-oxyphenyl)-bis(trifluoromethyl)methane and a ladder polyether with spirobisindane fragments on its base
by: I. M. Tkachenko, et al.
Published: (2015)

Antiproliferative activity and apoptosis induced by 6-bromo-2-(morpholin-1-yl)-4-anilinoquinazoline on cells of leukemia lines
by: Jantova, S., et al.
Published: (2008)

Evaluation of antiproliferative activity of pyrazolothiazolopyrimidine derivatives
by: N. S. Finiuk, et al.
Published: (2018)

Synthesis and diuretic properties of N-aryl-6-hydroxy-2-methyl-4-oxo-2,4-dihydro-1H-pyrrolo
by: I. V. Ukrainets, et al.
Published: (2013)

The synthesis and biological properties of hydroxy-(alkoxy)substituted anilides of 4-hydroxy-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acids
by: I. V. Ukrainets, et al.
Published: (2016)

Interrelation between 3-hydroxy-1,4-benzodiazepine-2-one esters structure on their hydrolysis by carboxyl esterase
by: Є. A. Shesterenko, et al.
Published: (2013)

Toxic and genotoxic effect of 1-(4-chlorobenzyl)-3-chloro-4-(trifluoromethyl-phenylamino)-1h-pyrol-2,5-dione in the test system Drosophila melanogaster Mg. (Diptera: Drosophilidae)
by: O. V. Protsenko, et al.
Published: (2017)

The synthesis and analgesic properties of N-(benzyl)-2-hydroxy-9-methyl-4-oxo-4N-pyrido(1,2-a)pyrimidine-3-carboxamides
by: I. V. Ukrainets, et al.
Published: (2015)

An efficient synthesis of PARP inhibitors containing a 4-trifluoromethyl substituted 3,6,7,7a-tetrahydro-1H-pyrrolo|3,4-d|pyrimidine-2,5-dione scaffold
by: O. O. Lukianov, et al.
Published: (2023)

Methylation of position 8 in the pyridine moiety of the N-(benzyl)-2-hydroxy-4-oxo-4N-pyrido(1,2-a)pyrimidine-3-carboxamide molecule as an attempt to enhance their analgesic properties
by: I. V. Ukrainets, et al.
Published: (2015)

&quot;Green&quot; synthesis of ethyl 4-hydroxy-2-oxo1,2-dihydroquinoline-3-carboxylates
by: I. V. Ukrainets, et al.
Published: (2013)

Cationic carboxamide derivatives of tricyclic heteroaromatic compounds: synthesis and preliminary evaluation of antiproliferative activity
by: V. G. Kostina, et al.
Published: (2020)

Design of 4-(4-dialkylaminostyryl) -pyridinium dyes for fluorescent detection of amyloid fibrils
by: D. I. Inshyn, et al.
Published: (2016)

The synthesis and the antitubercular activity of 1-benzyl-4-hydroxy-2-oxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxamides
by: O. O. Davidenko
Published: (2015)

Combined antiproliferative activity of imatinib mesylate (STI-571) with radiation or cisplatin in vitro
by: Yerushalmi, R., et al.
Published: (2007)

Polymorphism and the analgesic activity of N-(3-pyridylmethyl)-4-hydroxy-2-oxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxamide
by: I. V. Ukrainets, et al.
Published: (2015)

Antiproliferative and apoptotic effects of anti-human HB-EGF neutralizing polyclonal antibodies in vitro
by: Siromolot, A.A., et al.
Published: (2023)

Antiproliferative and apoptotic effect of ethanolic extract of Calocybe indica on PANC-1 and MIAPaCa2 cell lines of pancreatic cancer
by: Ghosh, S.K., et al.
Published: (2023)

Thermodynamics of 3-hydroxy-7-bromo-5-(2’-chloro)phenyl-1,2-dihydro-3H-1,4-benzodiazepine-2-ones esters complexation with the central benzodiazepine receptors
by: Smulsky, S.P., et al.
Published: (2012)

Modifications of 7-hydroxy-3-(benzothiazol-2-yl)coumarin
by: T. V. Shokol, et al.
Published: (2021)

The chemical composition and antiproliferative activity of fractions of the methanol extract from the basidiomes of Lactarius pergamenus (Fr.)Fr
by: L. V. Panchak, et al.
Published: (2012)

New spirobisindane-based ladder-type poly(arylene ether) copolymer with perfluorinated biphenylene and trifluoromethyl fragments
by: I. M. Tkachenko, et al.
Published: (2018)

The synthesis of 3-aryl-3-trifluoromethyl-2,3-dihydro-1H-pyrrolizin-1-ones
by: S. V. Melnykov, et al.
Published: (2019)

Cytoprotective effect of novel 4-thiazolidinone derivatives against stress conditions in small intestine of rats
by: I. I. Ilkiv, et al.
Published: (2017)

Stellarator fields with 2-wire lines wound round the torus (L=3,4 systems)
by: Kotenko, V.G., et al.
Published: (2000)

Evaluating the role of dithiolane rich fraction of Ferula asafoetida (apiaceae) for its antiproliferative and apoptotic properties: in vitro studies
by: Verma, S., et al.
Published: (2023)

The regularities of oxidation of N-hydroxy¬phthalimide with potassium permanganate in acidic medium
by: L. Opeida
Published: (2017)

DNA oxidation in patients with metastastic colorectal cancer: clinical significance of 8-hydroxy-deoxyguanosine as an independent prognostic factor
by: Burlaka, A.A., et al.
Published: (2023)

Interaction of cyanine dyes with nucleic acids. 4. Efficient 5-fluorescent labelling of oligonucleotides with monomethyne pyrylium cyanine dye, Cyan 39
by: Yarmoluk, S.M., et al.
Published: (1998)

Препаративний метод синтезу 4-(трифлуорометокси)піперидину та 4-(трифлуорометоксиметил)піперидину
by: Logvinenko, Ivan G., et al.
Published: (2021)

The synthesis, anti-inflammatory, analgesic and antimicrobial activities of ethyl 2-amino-4-alkyl-4,6-dihydropyrano(3,2-c)(2,1)benzothiazin-3-carboxylate 5,5-dioxides and triethylammonium 3-((4-hydroxy-1-ethyl-2,2-dioxido-1H-2,1-benzothiazin-3-yl)alkyl)-1
by: D. A. Lega, et al.
Published: (2016)

Selected 5-amino-1-aryl-1H-1,2,3-triazole scaffolds as promising antiproliferative agents
by: N. Pokhodylo, et al.
Published: (2020)

FEATURES OF GROUNDWATER QUALITY CHANGES DURING OPERATION OF WATER INTAKES IN THE LVIV REGION
by: Lyuta, N.G., et al.
Published: (2016)

СATALYTIC METHOD FOR THE SYNTHESIS OF 3-HYDROXY-2-NAPHTOIC ACID ANILIDE
by: Shteinberg, Leon
Published: (2022)

Synthesis and modification of 2-(coumarin-3-yl)-3,4,5,6,7,8-hexahydropyrido [4',3':4,5]thieno[2,3-d]pyrimidin-4-ones
by: Kovalenko, S.M., et al.
Published: (2010)

Antibiofilm Activity of 4-(Adamantyl-1)-1-(1-Aminobutyl) Benzol against Methicillin-Resistant Staphylococcus aureus
by: N. I. Hrynchuk, et al.
Published: (2022)

The study of regularities of the structure – analgesic activity relationship in a series of 4-hydroxy-N-(pyridin-2-yl)-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides
by: I. V. Ukrainets, et al.
Published: (2015)