Different effect of polymer-incorporated nanoparticles of Au and Ag on hematoporphyrin interaction with graft polymers

Different effect of polymer-incorporated nanoparticles of Au and Ag on hematoporphyrin interaction with graft polymers

One of the ways to improve the efficiency of photodynamic therapy is to enhance the accumulation of the photosensitizer (PS) in the tumor; for this, either polymers or metal nanoparticles (NP) could be used. Here we studied the effect of Au and Ag nanoparticles (AuNPs and AgNPs, respectively) synthe...

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Veröffentlicht in:Functional Materials
Datum:2019
Hauptverfasser: Losytskyy, M.Y., Kharchenko, R.A., Harahuts, Y.I., Shirinyan, E.A., Malinovska, Y.V., Kutsevol, N.V., Yashchuk, V.M.
Format: Artikel
Sprache:English
Veröffentlicht: НТК «Інститут монокристалів» НАН України 2019
Schlagworte:
Characterization and properties
Online Zugang:https://nasplib.isofts.kiev.ua/handle/123456789/157406
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Zitieren:Different effect of polymer-incorporated nanoparticles of Au and Ag on hematoporphyrin interaction with graft polymers / M.Y. Losytskyy, R.A. Kharchenko, Y.I. Harahuts, E.A. Shirinyan, Y.V. Malinovska, N.V. Kutsevol, V.M. Yashchuk // Functional Materials. — 2019. — Т. 26, № 1. — С. 107-113. — Бібліогр.: 25 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-157406
record_format dspace
spelling Losytskyy, M.Y.
Kharchenko, R.A.
Harahuts, Y.I.
Shirinyan, E.A.
Malinovska, Y.V.
Kutsevol, N.V.
Yashchuk, V.M.
2019-06-20T03:23:39Z
2019-06-20T03:23:39Z
2019
Different effect of polymer-incorporated nanoparticles of Au and Ag on hematoporphyrin interaction with graft polymers / M.Y. Losytskyy, R.A. Kharchenko, Y.I. Harahuts, E.A. Shirinyan, Y.V. Malinovska, N.V. Kutsevol, V.M. Yashchuk // Functional Materials. — 2019. — Т. 26, № 1. — С. 107-113. — Бібліогр.: 25 назв. — англ.
1027-5495
DOIhttps://doi.org/10.15407/fm26.01.107
https://nasplib.isofts.kiev.ua/handle/123456789/157406
One of the ways to improve the efficiency of photodynamic therapy is to enhance the accumulation of the photosensitizer (PS) in the tumor; for this, either polymers or metal nanoparticles (NP) could be used. Here we studied the effect of Au and Ag nanoparticles (AuNPs and AgNPs, respectively) synthesized in situ in solution of non-charged and anionic polymers on spectral properties of PS hematoporphyrin (HP) as well as on ¹O₂ generation by this compound (revealed by ¹O₂ emission at 1275 nm). The star-like copolymer Dextran-graft-Polyacrylamide (D-g-PAA) and its anionic form (D-g-PAAan) were used as polymer matrices for nanosystems preparation. Absorption and fluorescence spectra show that HP molecules bind to D-g-PAA and D-g-PAAan in water that leads to the destruction of HP aggregates; these changes are accompanied by increase of ¹O₂ generation. Meanwhile, in the presence of polymers with incorporated AgNPs (D-g-PAA/Ag and D-g-PAAac/Ag) the mentioned effect is stronger as compared to corresponding polymers without incorporated NPs. Thus AgNPs affect the graft polymers interaction with HP. Contrarily, the presence of both polymers with incorporated AuNPs enhances HP aggregation; besides, in the case of non-charged polymer with gold nanoparticles D-g-PAA/Au, Au nanoparticles induce appearing of different HP form, presumably protonated one. Effect of Ag and Au nanoparticles on fluorescent properties of HP is mainly determined by the effect of these NPs on aggregation of HP (and, in the case of D-g-PAA/Au, by appearing of different HP form). As for HP-sensitized singlet oxygen luminescence, effect of AgNPs is also mainly related to aggregation destruction, while this of Au nanoparticles could have other mechanisms as well.
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НТК «Інститут монокристалів» НАН України
Functional Materials
Characterization and properties
Different effect of polymer-incorporated nanoparticles of Au and Ag on hematoporphyrin interaction with graft polymers
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title Different effect of polymer-incorporated nanoparticles of Au and Ag on hematoporphyrin interaction with graft polymers
spellingShingle Different effect of polymer-incorporated nanoparticles of Au and Ag on hematoporphyrin interaction with graft polymers
Losytskyy, M.Y.
Kharchenko, R.A.
Harahuts, Y.I.
Shirinyan, E.A.
Malinovska, Y.V.
Kutsevol, N.V.
Yashchuk, V.M.
Characterization and properties
title_short Different effect of polymer-incorporated nanoparticles of Au and Ag on hematoporphyrin interaction with graft polymers
title_full Different effect of polymer-incorporated nanoparticles of Au and Ag on hematoporphyrin interaction with graft polymers
title_fullStr Different effect of polymer-incorporated nanoparticles of Au and Ag on hematoporphyrin interaction with graft polymers
title_full_unstemmed Different effect of polymer-incorporated nanoparticles of Au and Ag on hematoporphyrin interaction with graft polymers
title_sort different effect of polymer-incorporated nanoparticles of au and ag on hematoporphyrin interaction with graft polymers
author Losytskyy, M.Y.
Kharchenko, R.A.
Harahuts, Y.I.
Shirinyan, E.A.
Malinovska, Y.V.
Kutsevol, N.V.
Yashchuk, V.M.
author_facet Losytskyy, M.Y.
Kharchenko, R.A.
Harahuts, Y.I.
Shirinyan, E.A.
Malinovska, Y.V.
Kutsevol, N.V.
Yashchuk, V.M.
topic Characterization and properties
topic_facet Characterization and properties
publishDate 2019
language English
container_title Functional Materials
publisher НТК «Інститут монокристалів» НАН України
format Article
description One of the ways to improve the efficiency of photodynamic therapy is to enhance the accumulation of the photosensitizer (PS) in the tumor; for this, either polymers or metal nanoparticles (NP) could be used. Here we studied the effect of Au and Ag nanoparticles (AuNPs and AgNPs, respectively) synthesized in situ in solution of non-charged and anionic polymers on spectral properties of PS hematoporphyrin (HP) as well as on ¹O₂ generation by this compound (revealed by ¹O₂ emission at 1275 nm). The star-like copolymer Dextran-graft-Polyacrylamide (D-g-PAA) and its anionic form (D-g-PAAan) were used as polymer matrices for nanosystems preparation. Absorption and fluorescence spectra show that HP molecules bind to D-g-PAA and D-g-PAAan in water that leads to the destruction of HP aggregates; these changes are accompanied by increase of ¹O₂ generation. Meanwhile, in the presence of polymers with incorporated AgNPs (D-g-PAA/Ag and D-g-PAAac/Ag) the mentioned effect is stronger as compared to corresponding polymers without incorporated NPs. Thus AgNPs affect the graft polymers interaction with HP. Contrarily, the presence of both polymers with incorporated AuNPs enhances HP aggregation; besides, in the case of non-charged polymer with gold nanoparticles D-g-PAA/Au, Au nanoparticles induce appearing of different HP form, presumably protonated one. Effect of Ag and Au nanoparticles on fluorescent properties of HP is mainly determined by the effect of these NPs on aggregation of HP (and, in the case of D-g-PAA/Au, by appearing of different HP form). As for HP-sensitized singlet oxygen luminescence, effect of AgNPs is also mainly related to aggregation destruction, while this of Au nanoparticles could have other mechanisms as well.
issn 1027-5495
url https://nasplib.isofts.kiev.ua/handle/123456789/157406
fulltext
citation_txt Different effect of polymer-incorporated nanoparticles of Au and Ag on hematoporphyrin interaction with graft polymers / M.Y. Losytskyy, R.A. Kharchenko, Y.I. Harahuts, E.A. Shirinyan, Y.V. Malinovska, N.V. Kutsevol, V.M. Yashchuk // Functional Materials. — 2019. — Т. 26, № 1. — С. 107-113. — Бібліогр.: 25 назв. — англ.
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first_indexed 2025-11-25T20:56:21Z
last_indexed 2025-11-25T20:56:21Z
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