The gene expression pattern as a tool for assessment of components of microenvironment and response to anti-cancer therapy of prostate tumors
We have analyzed the putative value of the pattern of relative expression (RE) of several genes that might be involved in a response to anti-cancer therapy, namely AR, PTEN, COX2, FASN, HMGCR, LDLR, and CTLA4, in samples of prostate adenoma, adenocarcinoma, and the paired conventional normal tissu...
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| Date: | 2019 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
Видавничий дім "Академперіодика" НАН України
2019
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| Series: | Доповіді НАН України |
| Subjects: | |
| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/158098 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | The gene expression pattern as a tool for assessment of components of microenvironment and response to anti-cancer therapy of prostate tumors / G.V. Gerashchenko, L.I. Chashchina, A.V. Rynditch, V.I. Kashuba // Доповіді Національної академії наук України. — 2019. — № 4. — С. 86-93. — Бібліогр.: 15 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| Summary: | We have analyzed the putative value of the pattern of relative expression (RE) of several genes that might be involved
in a response to anti-cancer therapy, namely AR, PTEN, COX2, FASN, HMGCR, LDLR, and CTLA4, in samples of
prostate adenoma, adenocarcinoma, and the paired conventional normal tissues. We could propose three subtypes of
adenocarcinomas that show the distinct pattern of expression of the above-mentioned genes, characteristics for (1)
cancer-associated fibroblasts (CAFs), (2) tumor-associated macrophages (TAMs), and (3) markers of immune response.
These groups correlate with the prostate cancer subtypes, that were determined earlier, based on the analysis
of RE of the epithelial-to-mesenchymal cell transition (EMT) genes and prostate cancer-associated genes. Noteworthy,
the highest correlation was found for genes characteristic of CAFs. This emphasizes the importance of the
simultaneous analysis of genes, involved in various intercellular interactions between tumor cells and cells of tumor
microenvironment, in prediction of efficacy of anti-cancer therapy. To confirm the presented data, the additional
studies on a larger cohort of the prostate cancer patients are required. |
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