Сигнальна функція β-катеніну при адаптації дорослого міокарда ссавців до фізичних навантажень
Aims. Our current work is devoted to the adaptation of the myocardium of wild-type and animals with embryonic
 cardiospecifi c haploinsuffi ciency of β-catenin to physical training, namely smimming. Methods. Trangenic and wild-type
 animals were subjected to swimming test. The qPCR a...
Збережено в:
| Опубліковано в: : | Фактори експериментальної еволюції організмів |
|---|---|
| Дата: | 2015 |
| Автори: | , , , , |
| Формат: | Стаття |
| Мова: | Українська |
| Опубліковано: |
Інститут молекулярної біології і генетики НАН України
2015
|
| Теми: | |
| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/177400 |
| Теги: |
Додати тег
Немає тегів, Будьте першим, хто поставить тег для цього запису!
|
| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Сигнальна функція β-катеніну при адаптації дорослого міокарда ссавців до фізичних навантажень / О.Л. Пальчевська, В.В. Балацький, Л.Л. Мацевич, О.О. Півень, Л.Л. Лукаш // Фактори експериментальної еволюції організмів: Зб. наук. пр. — 2015. — Т. 16. — С. 225-229. — Бібліогр.: 19 назв. — укр. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| Резюме: | Aims. Our current work is devoted to the adaptation of the myocardium of wild-type and animals with embryonic
cardiospecifi c haploinsuffi ciency of β-catenin to physical training, namely smimming. Methods. Trangenic and wild-type
animals were subjected to swimming test. The qPCR analysis of hypertrohic (ANP, BNP, β-MHC and α-MHC) and Wnt/
β-catenin pathway target genes (TCF4 and c-myc) was performed for control and trained mice. The HW/BW index was
calculated to estimate myocardium hypertrophy development. Results. The increase of HW/BW index for trained animals
was shown. The increase of hypertrophic genes (ANP, BNP, β-MHC, and α-MHC) were detected in both trained and
control animals with β-catenin gene haploinsuffi ciency. It is also important to note that Wnt target genes were upregulated
only in the β-catenin haploinsuffi cient stressed animals. Conclusions. The results show that β-catenin gene defi ciency
leads to fetal (hypertrophic) genes violation even for unstressed animals. The activation of Wnt-signaling pathway was
detected during adult myocardium adaptation to physical stress. These observations point to the conclusion that β-catenin
gene function plays important role in the heart adaptation and remodeling during stress.
Keywords: physiological cardiac hypertrophy, β-catenin haploinsuffi ciency, canonical Wnt signaling, heart adaptation,
physical training.
|
|---|---|
| ISSN: | 2219-3782 |