Однонуклеотидный полиморфизм гена интерлейкина-6 (IL-6) у жителей Харькова, больных сахарным диабетом 2 типа
Aims. To examine the association between SNP rs2069840 (174G / C) of interleukin-6 gene and type 2 diabetes in the population of Kharkov. Objects were venous blood samples of 60 patients with type 2 diabetes and 49 healthy persons (all residents of Kharkiv, Ukrainian and Russian). Methods. Genotypin...
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| Published in: | Фактори експериментальної еволюції організмів |
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| Date: | 2015 |
| Main Authors: | , , , , |
| Format: | Article |
| Language: | Russian |
| Published: |
Інститут молекулярної біології і генетики НАН України
2015
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| Subjects: | |
| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/177405 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Однонуклеотидный полиморфизм гена интерлейкина-6 (IL-6) у жителей Харькова, больных сахарным диабетом 2 типа / Н.А. Козак, А.К. Почерняев, Д.В. Лыткин, М.Ю. Горшунская, С.С. Почерняева // Фактори експериментальної еволюції організмів: Зб. наук. пр. — 2015. — Т. 16. — С. 206-209. — Бібліогр.: 13 назв. — рос. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| Summary: | Aims. To examine the association between SNP rs2069840 (174G / C) of interleukin-6 gene and type 2 diabetes in the population of Kharkov. Objects were venous blood samples of 60 patients with type 2 diabetes and 49 healthy persons (all residents of Kharkiv, Ukrainian and Russian). Methods. Genotyping by PCR-RFLP. Results. The distribution of genotypes for SNP rs2069840 corresponds to the Hardy-Weinberg equilibrium. Allele frequencies in the control group is 0.5; in the group of patients pC = 0.4, qG = 0.6. The weak non-signifi cant association between CC genotype and type 2 diabetes was marked. The odds ratio for genotype GG is 0.54. The sensitivity of the test is 15 %, specificity — 76 %. The positive predictive value is equal to 2 %, negative — 97 %, the accuracy of the test is 74 %, positive likelihood ratio result is 0.63, a negative — 1.6. Conclusions. The distribution of genotypes for SNP rs2069840 of interleukin-6 in the Kharkov population does not deviate from the Hardy-Weinberg equilibrium. According to the results of a pilot study was founded that the CC genotype increases the risk of type 2 diabetes in 1.2 times.
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| ISSN: | 2219-3782 |