Імуномодулювальні i противірусні властивості базидіального гриба Trametes versicolor
Aims. The aim of current work was to assess the cytotoxicity and antiviral activity of culture broth from higher
 basidiomycetes Trametes versicolor 353 in culture cell HEP-2 and to investigate the effect of biomass T. versicolor 353
 on the immunoreactivity indicators on experimenta...
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| Veröffentlicht in: | Фактори експериментальної еволюції організмів |
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| Datum: | 2015 |
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | Ukrainisch |
| Veröffentlicht: |
Інститут молекулярної біології і генетики НАН України
2015
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| Schlagworte: | |
| Online Zugang: | https://nasplib.isofts.kiev.ua/handle/123456789/177530 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Zitieren: | Імуномодулювальні i противірусні властивості базидіального гриба Trametes versicolor / Л.О. Тітова, І.Р. Клечак, О.П. Трохименко, Л.М. Лазаренко, О.М. Дуган // Фактори експериментальної еволюції організмів: Зб. наук. пр. — 2015. — Т. 17. — С. 253-257. — Бібліогр.: 11 назв. — укр. |
Institution
Digital Library of Periodicals of National Academy of Sciences of Ukraine| Zusammenfassung: | Aims. The aim of current work was to assess the cytotoxicity and antiviral activity of culture broth from higher
basidiomycetes Trametes versicolor 353 in culture cell HEP-2 and to investigate the effect of biomass T. versicolor 353
on the immunoreactivity indicators on experimental model in vivo. Methods. The cytotoxicity and antiviral properties of
culture broth of T. versicolor 353 studied using standard methods in cell culture. Functional activity of peritoneal exudate
macrophages was determined spectrophotometric method. Тhe content of TNF-α in serum was determined by standard
procedure for cytotoxic effects on cell culture L-929. Results. It was established that the cytotoxic effect of all the samples
of the culture broth depends on the composition medium and the duration of their effects on cell monolayer. It was shown
that that samples no possess direct antiviral activity against investigated the viruses. Introduction mice the suspension of
biomass T. versicolor 353 led to activation of endogenous interferon and not affected the production of proinflammatory
cytokines. Conclusions. The biomass of T. versicolor 353 may be a promising material for the creation products with
immunomodulating activities.
Keywords: immunomodulating, antiviral activity, Trametes versicolor, low cytotoxicity, endogenous interferon.
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| ISSN: | 2219-3782 |