Анализ связи количественных характеристик женщин и полученных от них эмбрионов в программах ВРТ

• Опубліковано в: : Фактори експериментальної еволюції організмів
• Дата: 2016
• Автори: Гонтарь, Ю.В., Лахно, Я.В., Ильин, И.Е., Федота, А.М.
• Формат: Стаття
• Мова: Російська
• Опубліковано: Інститут молекулярної біології і генетики НАН України 2016
• Теми: Генетика людини та медична генетика
• Онлайн доступ: https://nasplib.isofts.kiev.ua/handle/123456789/177617
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Цитувати: Анализ связи количественных характеристик женщин и полученных от них эмбрионов в программах ВРТ / Ю.В. Гонтарь, Я.В. Лахно, И.Е. Ильин, А.М. Федота // Фактори експериментальної еволюції організмів: Зб. наук. пр. — 2016. — Т. 18. — С. 223-226. — Бібліогр.: 10 назв. — рос.

Aim. Analysis of relationship between response rates of women of different ages on the superovulation and embryo
 parameters derived from these women in programs of assisted reproductive technologies. Methods. Research of nondisjunction chromosomes in preimplantation embryos based on the results of diagnostics of 5442 from 504 ICSI + PGD
 programs. Stimulation of superovulation was carried out on a long luteal protocol using agonists of luteinizing hormone
 releasing hormone (LHRH). During the preimplantation genetic diagnosis (PGD) in the blastomeres FISH method was
 used. Probes for chromosomes 13, 16, 18, 21, 22, X, Y were used. Researching of relations between signs carried out by
 correlation analysis of Pearson and Spearman. Results. 1386 (25.5%) embryos from 5442 are defined as euploid. There
 is a direct correlation between the average age of women and the proportion of euploid embryos produced in one cycle of
 ovarian stimulation (r = 0.39), between the number of embryos per cycle in women and the number of euploid embryos
 per cycle (r = 0.65). There is an inverse relationship between the number of embryos per cycle of ovarian stimulation and
 middle-aged women (r = –0.74), between the age of patients and the number of euploid embryos per cycle of ovarian
 stimulation (r = –0.29), between the age of patients and the number of embryos in the ovarian cycle stimulation (r =
 –0.31). Conclusions. Age characteristics of the patients have a significant effect on the response to ovarian stimulation,
 and the number of euploid embryos stimulation cycle. Given that 75% of embryos obtained in ART programs have
 chromosomal aneuploidy, an effective strategy is to assign pairs of preimplantation genetic screening, where a woman’s
 age is critical for the prevention of chromosomal aberrations in the preimplantation period of ontogenesis.
 Keywords: preimplantation genetic diagnosis, assisted reproductive technologies, aneuploid embryos, response to ovarian
 stimulation.