Анализ однонуклеотидных полиморфизмов генов MTHFR и MTRR у больных псориазом
Aim. Analysis of single nucleotide polymorphisms C677T, A1298C and A66G of MTHFR and MTRR one-carbon metabolism genes in patients with various forms of psoriasis in Ukrainian population. Methods. A molecular genetic analysis of 77 patients with vulgaris and arthropathic psoriasis by PCR-RFLP was c...
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| Published in: | Фактори експериментальної еволюції організмів |
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| Date: | 2016 |
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| Language: | Russian |
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Інститут молекулярної біології і генетики НАН України
2016
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/177650 |
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| Cite this: | Анализ однонуклеотидных полиморфизмов генов MTHFR и MTRR у больных псориазом / А.М. Федота, Л.В. Рощенюк, И.В. Горайчук, Т.В. Тыжненко, А.В. Адмакина // Фактори експериментальної еволюції організмів: Зб. наук. пр. — 2016. — Т. 18. — С. 257-261. — Бібліогр.: 24 назв. — рос. |
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Федота, А.М. Рощенюк, Л.В. Горайчук, И.В. Тыжненко, Т.В. Адмакина, А.В. 2021-02-16T13:54:22Z 2021-02-16T13:54:22Z 2016 Анализ однонуклеотидных полиморфизмов генов MTHFR и MTRR у больных псориазом / А.М. Федота, Л.В. Рощенюк, И.В. Горайчук, Т.В. Тыжненко, А.В. Адмакина // Фактори експериментальної еволюції організмів: Зб. наук. пр. — 2016. — Т. 18. — С. 257-261. — Бібліогр.: 24 назв. — рос. 2219-3782 https://nasplib.isofts.kiev.ua/handle/123456789/177650 575.1:575.174.015.3-616.517 Aim. Analysis of single nucleotide polymorphisms C677T, A1298C and A66G of MTHFR and MTRR one-carbon metabolism genes in patients with various forms of psoriasis in Ukrainian population. Methods. A molecular genetic analysis of 77 patients with vulgaris and arthropathic psoriasis by PCR-RFLP was carried out. Results. In patients with vulgaris and arthropathic psoriasis analysis of the distribution of frequencies of genotypes showed a statistically significant difference between them for A66G and C677T polymorphic variants. In patients with psoriasis analysis of genotype distribution of series in the two genes as a whole, showed a statistically significant difference between the theoretically expected and actual frequencies for single nucleotide polymorphisms A1298T and A66G of MTHFR and MTRR genes. Conclusions. Among patients with arthropatic psoriasis, which is the most severe form of psoriasis, the homozygotes for the wild-type allele A of A66G of MTRR gene are more common, homozygotes of the TT of C667T of MTHFR gene are found more rarely than among psoriasis vulgaris patients, which may indicate the contribution of other genes to the development of arthropatic psoriasis. Keywords: psoriasis, arthropatic psoriasis, folate cycle, MTHFR gene, MTRR gene. ru Інститут молекулярної біології і генетики НАН України Фактори експериментальної еволюції організмів Генетика людини та медична генетика Анализ однонуклеотидных полиморфизмов генов MTHFR и MTRR у больных псориазом Analysis of SNP’s of MTHFR and MTRR genes in patients with psoriasis Article published earlier |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| title |
Анализ однонуклеотидных полиморфизмов генов MTHFR и MTRR у больных псориазом |
| spellingShingle |
Анализ однонуклеотидных полиморфизмов генов MTHFR и MTRR у больных псориазом Федота, А.М. Рощенюк, Л.В. Горайчук, И.В. Тыжненко, Т.В. Адмакина, А.В. Генетика людини та медична генетика |
| title_short |
Анализ однонуклеотидных полиморфизмов генов MTHFR и MTRR у больных псориазом |
| title_full |
Анализ однонуклеотидных полиморфизмов генов MTHFR и MTRR у больных псориазом |
| title_fullStr |
Анализ однонуклеотидных полиморфизмов генов MTHFR и MTRR у больных псориазом |
| title_full_unstemmed |
Анализ однонуклеотидных полиморфизмов генов MTHFR и MTRR у больных псориазом |
| title_sort |
анализ однонуклеотидных полиморфизмов генов mthfr и mtrr у больных псориазом |
| author |
Федота, А.М. Рощенюк, Л.В. Горайчук, И.В. Тыжненко, Т.В. Адмакина, А.В. |
| author_facet |
Федота, А.М. Рощенюк, Л.В. Горайчук, И.В. Тыжненко, Т.В. Адмакина, А.В. |
| topic |
Генетика людини та медична генетика |
| topic_facet |
Генетика людини та медична генетика |
| publishDate |
2016 |
| language |
Russian |
| container_title |
Фактори експериментальної еволюції організмів |
| publisher |
Інститут молекулярної біології і генетики НАН України |
| format |
Article |
| title_alt |
Analysis of SNP’s of MTHFR and MTRR genes in patients with psoriasis |
| description |
Aim. Analysis of single nucleotide polymorphisms C677T, A1298C and A66G of MTHFR and MTRR one-carbon
metabolism genes in patients with various forms of psoriasis in Ukrainian population. Methods. A molecular genetic
analysis of 77 patients with vulgaris and arthropathic psoriasis by PCR-RFLP was carried out. Results. In patients with
vulgaris and arthropathic psoriasis analysis of the distribution of frequencies of genotypes showed a statistically significant
difference between them for A66G and C677T polymorphic variants. In patients with psoriasis analysis of genotype
distribution of series in the two genes as a whole, showed a statistically significant difference between the theoretically
expected and actual frequencies for single nucleotide polymorphisms A1298T and A66G of MTHFR and MTRR genes.
Conclusions. Among patients with arthropatic psoriasis, which is the most severe form of psoriasis, the homozygotes
for the wild-type allele A of A66G of MTRR gene are more common, homozygotes of the TT of C667T of MTHFR gene
are found more rarely than among psoriasis vulgaris patients, which may indicate the contribution of other genes to the
development of arthropatic psoriasis.
Keywords: psoriasis, arthropatic psoriasis, folate cycle, MTHFR gene, MTRR gene.
|
| issn |
2219-3782 |
| url |
https://nasplib.isofts.kiev.ua/handle/123456789/177650 |
| citation_txt |
Анализ однонуклеотидных полиморфизмов генов MTHFR и MTRR у больных псориазом / А.М. Федота, Л.В. Рощенюк, И.В. Горайчук, Т.В. Тыжненко, А.В. Адмакина // Фактори експериментальної еволюції організмів: Зб. наук. пр. — 2016. — Т. 18. — С. 257-261. — Бібліогр.: 24 назв. — рос. |
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2025-12-07T17:01:00Z |
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