Plant and animal lectines as modulators of mgmt and marp gene expression in vitro

Plant and animal lectines as modulators of mgmt and marp gene expression in vitro

Aims. Previously for the first time we have studied the ability of lectins to influence the processes of mutagenesis and antimutagenesis in different test systems. The aim of present study was to examine the effect of panel of lectins on the MGMT and MARP expression levels in tumor and non-tumor mam...

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Date:2014
Main Authors: Macewicz, L.L., Lylo, V.V., Karpova, I.S., Kotsarenko, K.V., Ruban, T.A., Lukash, L.L.
Format: Article
Language:English
Published: Інститут молекулярної біології і генетики НАН України 2014
Series:Фактори експериментальної еволюції організмів
Subjects:
Прикладна генетика і селекція
Online Access:https://nasplib.isofts.kiev.ua/handle/123456789/178342
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Journal Title:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Cite this:Plant and animal lectines as modulators of mgmt and marp gene expression in vitro / L.L. Macewicz, V.V. Lylo, I.S. Karpova, K.V. Kotsarenko, T.A. Ruban, L.L. Lukash // Фактори експериментальної еволюції організмів: Зб. наук. пр. — 2014. — Т. 15. — С. 260-264. — Бібліогр.: 26 назв. — англ.

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spelling nasplib_isofts_kiev_ua-123456789-1783422025-02-09T13:02:54Z Plant and animal lectines as modulators of mgmt and marp gene expression in vitro Macewicz, L.L. Lylo, V.V. Karpova, I.S. Kotsarenko, K.V. Ruban, T.A. Lukash, L.L. Прикладна генетика і селекція Aims. Previously for the first time we have studied the ability of lectins to influence the processes of mutagenesis and antimutagenesis in different test systems. The aim of present study was to examine the effect of panel of lectins on the MGMT and MARP expression levels in tumor and non-tumor mammalian cells in vitro. Methods. Standard cell cultivation methods and Western blot analysis were used. Results. The influence of plant and animal lectins (perk egg lectin, lentil seeds lectin and elderberry bark lectin) on expressiom of proteins recognized by anti-MGMT monoclonal antibodies (MGMT and MARP) on stable and destabilized human non-tumor and tumor-derived cell lines was studied. Conclusions. Studied lectins are able to modulate the expression of MGMT and MARP. The influence of SNA-I on MARP and MGMT expression levels depends on origin and genomic stability of cell line. SNA-I is perspective for further study as potential drug in anti-tumor therapy optimization schemes. Key words: MGMT expression, MARP expression, lectins, NiCl2, cell lines. 2014 Article Plant and animal lectines as modulators of mgmt and marp gene expression in vitro / L.L. Macewicz, V.V. Lylo, I.S. Karpova, K.V. Kotsarenko, T.A. Ruban, L.L. Lukash // Фактори експериментальної еволюції організмів: Зб. наук. пр. — 2014. — Т. 15. — С. 260-264. — Бібліогр.: 26 назв. — англ. 2219-3782 https://nasplib.isofts.kiev.ua/handle/123456789/178342 575.224 en Фактори експериментальної еволюції організмів application/pdf Інститут молекулярної біології і генетики НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Прикладна генетика і селекція
Прикладна генетика і селекція
spellingShingle Прикладна генетика і селекція
Прикладна генетика і селекція
Macewicz, L.L.
Lylo, V.V.
Karpova, I.S.
Kotsarenko, K.V.
Ruban, T.A.
Lukash, L.L.
Plant and animal lectines as modulators of mgmt and marp gene expression in vitro
Фактори експериментальної еволюції організмів
description Aims. Previously for the first time we have studied the ability of lectins to influence the processes of mutagenesis and antimutagenesis in different test systems. The aim of present study was to examine the effect of panel of lectins on the MGMT and MARP expression levels in tumor and non-tumor mammalian cells in vitro. Methods. Standard cell cultivation methods and Western blot analysis were used. Results. The influence of plant and animal lectins (perk egg lectin, lentil seeds lectin and elderberry bark lectin) on expressiom of proteins recognized by anti-MGMT monoclonal antibodies (MGMT and MARP) on stable and destabilized human non-tumor and tumor-derived cell lines was studied. Conclusions. Studied lectins are able to modulate the expression of MGMT and MARP. The influence of SNA-I on MARP and MGMT expression levels depends on origin and genomic stability of cell line. SNA-I is perspective for further study as potential drug in anti-tumor therapy optimization schemes. Key words: MGMT expression, MARP expression, lectins, NiCl2, cell lines.
format Article
author Macewicz, L.L.
Lylo, V.V.
Karpova, I.S.
Kotsarenko, K.V.
Ruban, T.A.
Lukash, L.L.
author_facet Macewicz, L.L.
Lylo, V.V.
Karpova, I.S.
Kotsarenko, K.V.
Ruban, T.A.
Lukash, L.L.
author_sort Macewicz, L.L.
title Plant and animal lectines as modulators of mgmt and marp gene expression in vitro
title_short Plant and animal lectines as modulators of mgmt and marp gene expression in vitro
title_full Plant and animal lectines as modulators of mgmt and marp gene expression in vitro
title_fullStr Plant and animal lectines as modulators of mgmt and marp gene expression in vitro
title_full_unstemmed Plant and animal lectines as modulators of mgmt and marp gene expression in vitro
title_sort plant and animal lectines as modulators of mgmt and marp gene expression in vitro
publisher Інститут молекулярної біології і генетики НАН України
publishDate 2014
topic_facet Прикладна генетика і селекція
url https://nasplib.isofts.kiev.ua/handle/123456789/178342
citation_txt Plant and animal lectines as modulators of mgmt and marp gene expression in vitro / L.L. Macewicz, V.V. Lylo, I.S. Karpova, K.V. Kotsarenko, T.A. Ruban, L.L. Lukash // Фактори експериментальної еволюції організмів: Зб. наук. пр. — 2014. — Т. 15. — С. 260-264. — Бібліогр.: 26 назв. — англ.
series Фактори експериментальної еволюції організмів
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AT lylovv plantandanimallectinesasmodulatorsofmgmtandmarpgeneexpressioninvitro
AT karpovais plantandanimallectinesasmodulatorsofmgmtandmarpgeneexpressioninvitro
AT kotsarenkokv plantandanimallectinesasmodulatorsofmgmtandmarpgeneexpressioninvitro
AT rubanta plantandanimallectinesasmodulatorsofmgmtandmarpgeneexpressioninvitro
AT lukashll plantandanimallectinesasmodulatorsofmgmtandmarpgeneexpressioninvitro
first_indexed 2025-11-26T01:39:48Z
last_indexed 2025-11-26T01:39:48Z
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