The antimicrobial activity of magnetron sputtered Ag doped aluminum oxide coatings in vitro
The effect of Ag-doped aluminium oxide coatings deposited by magnetron sputtering method on the antibacterial efficiency against Gram-positive, Gram-negative bacteria and fungi has been investigated. The structure and composition of coatings were analysed by means of scanning electron microscopy (SE...
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| Zitieren: | The antimicrobial activity of magnetron sputtered Ag doped aluminum oxide coatings in vitro / V. Safonov, N. Donkov, A. Zykova, L. Avramov, S. Dudin, S. Yakovin, H. Naidenski, I. Avramova // Problems of atomic science and technology. — 2019. — № 1. — С. 187-189. — Бібліогр.: 10 назв. — англ. |
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Safonov, V. Donkov, N. Zykova, A. Avramov, L. Dudin, S. Yakovin, S. Naidenski, H. Avramova, I. 2023-11-29T09:25:42Z 2023-11-29T09:25:42Z 2019 The antimicrobial activity of magnetron sputtered Ag doped aluminum oxide coatings in vitro / V. Safonov, N. Donkov, A. Zykova, L. Avramov, S. Dudin, S. Yakovin, H. Naidenski, I. Avramova // Problems of atomic science and technology. — 2019. — № 1. — С. 187-189. — Бібліогр.: 10 назв. — англ. 1562-6016 PACS: 87.80 Rb https://nasplib.isofts.kiev.ua/handle/123456789/194716 The effect of Ag-doped aluminium oxide coatings deposited by magnetron sputtering method on the antibacterial efficiency against Gram-positive, Gram-negative bacteria and fungi has been investigated. The structure and composition of coatings were analysed by means of scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), photoelectron spectroscopy (XPS) methods. The results of the study suggest that Ag-doped aluminium oxide coatings demonstrate improved bactericidal effect and have great potential in various medical applications. Досліджено вплив покриттів оксиду алюмінію зі сріблом, нанесених методом магнетронного напилення на антибактеріальну ефективність проти грампозитивних, грамнегативних бактерій та грибків. Структура та склад покриттів були проаналізовані за допомогою скануючої електронної мікроскопії (SEM), енергодисперсійної рентгенівської спектроскопії (EDS), методів фотоелектронної спектроскопії (XPS). Результати дослідження дозволяють стверджувати, що покриття оксиду алюмінію зі сріблом демонструють поліпшений бактерицидний ефект і мають великий потенціал використання в різних галузях медицини. Исследовано влияние покрытий оксида алюминия с серебром, нанесенных методом магнетронного напыления на антибактериальную эффективность против грамположительных, грамотрицательных бактерий и грибков. Структура и состав покрытий были проанализированы с помощью сканирующей электронной микроскопии (SEM), энергодисперсионной рентгеновской спектроскопии (EDS), методов фотоэлектронной спектроскопии (XPS). Результаты исследования позволяют утверждать, что покрытия оксида алюминия с серебром демонстрируют улучшенный бактерицидный эффект и имеют большой потенциал применения в различных областях медицины. The research was supported by the international scientific cooperation program of Bulgarian-Ukrainian Academies of Science, and international scientific cooperation project between National Academy of Science of Ukraine and Belarusian Academy of Science № 17-3-18. en Національний науковий центр «Харківський фізико-технічний інститут» НАН України Вопросы атомной науки и техники Low temperature plasma and plasma technologies The antimicrobial activity of magnetron sputtered Ag doped aluminum oxide coatings in vitro Антимікробна активність покриття оксиду алюмінію зі сріблом, нанесеним магнетронним розпиленням у тестах in vitro Антимикробная активность покрытия оксида алюминия с серебром, нанесенного методом магнетронного распыления в тестах in vitro Article published earlier |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| title |
The antimicrobial activity of magnetron sputtered Ag doped aluminum oxide coatings in vitro |
| spellingShingle |
The antimicrobial activity of magnetron sputtered Ag doped aluminum oxide coatings in vitro Safonov, V. Donkov, N. Zykova, A. Avramov, L. Dudin, S. Yakovin, S. Naidenski, H. Avramova, I. Low temperature plasma and plasma technologies |
| title_short |
The antimicrobial activity of magnetron sputtered Ag doped aluminum oxide coatings in vitro |
| title_full |
The antimicrobial activity of magnetron sputtered Ag doped aluminum oxide coatings in vitro |
| title_fullStr |
The antimicrobial activity of magnetron sputtered Ag doped aluminum oxide coatings in vitro |
| title_full_unstemmed |
The antimicrobial activity of magnetron sputtered Ag doped aluminum oxide coatings in vitro |
| title_sort |
antimicrobial activity of magnetron sputtered ag doped aluminum oxide coatings in vitro |
| author |
Safonov, V. Donkov, N. Zykova, A. Avramov, L. Dudin, S. Yakovin, S. Naidenski, H. Avramova, I. |
| author_facet |
Safonov, V. Donkov, N. Zykova, A. Avramov, L. Dudin, S. Yakovin, S. Naidenski, H. Avramova, I. |
| topic |
Low temperature plasma and plasma technologies |
| topic_facet |
Low temperature plasma and plasma technologies |
| publishDate |
2019 |
| language |
English |
| container_title |
Вопросы атомной науки и техники |
| publisher |
Національний науковий центр «Харківський фізико-технічний інститут» НАН України |
| format |
Article |
| title_alt |
Антимікробна активність покриття оксиду алюмінію зі сріблом, нанесеним магнетронним розпиленням у тестах in vitro Антимикробная активность покрытия оксида алюминия с серебром, нанесенного методом магнетронного распыления в тестах in vitro |
| description |
The effect of Ag-doped aluminium oxide coatings deposited by magnetron sputtering method on the antibacterial efficiency against Gram-positive, Gram-negative bacteria and fungi has been investigated. The structure and composition of coatings were analysed by means of scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), photoelectron spectroscopy (XPS) methods. The results of the study suggest that Ag-doped aluminium oxide coatings demonstrate improved bactericidal effect and have great potential in various medical applications.
Досліджено вплив покриттів оксиду алюмінію зі сріблом, нанесених методом магнетронного напилення на антибактеріальну ефективність проти грампозитивних, грамнегативних бактерій та грибків. Структура та склад покриттів були проаналізовані за допомогою скануючої електронної мікроскопії (SEM), енергодисперсійної рентгенівської спектроскопії (EDS), методів фотоелектронної спектроскопії (XPS). Результати дослідження дозволяють стверджувати, що покриття оксиду алюмінію зі сріблом демонструють поліпшений бактерицидний ефект і мають великий потенціал використання в різних галузях медицини.
Исследовано влияние покрытий оксида алюминия с серебром, нанесенных методом магнетронного напыления на антибактериальную эффективность против грамположительных, грамотрицательных бактерий и грибков. Структура и состав покрытий были проанализированы с помощью сканирующей электронной микроскопии (SEM), энергодисперсионной рентгеновской спектроскопии (EDS), методов фотоэлектронной спектроскопии (XPS). Результаты исследования позволяют утверждать, что покрытия оксида алюминия с серебром демонстрируют улучшенный бактерицидный эффект и имеют большой потенциал применения в различных областях медицины.
|
| issn |
1562-6016 |
| url |
https://nasplib.isofts.kiev.ua/handle/123456789/194716 |
| citation_txt |
The antimicrobial activity of magnetron sputtered Ag doped aluminum oxide coatings in vitro / V. Safonov, N. Donkov, A. Zykova, L. Avramov, S. Dudin, S. Yakovin, H. Naidenski, I. Avramova // Problems of atomic science and technology. — 2019. — № 1. — С. 187-189. — Бібліогр.: 10 назв. — англ. |
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2025-11-24T03:06:11Z |
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2025-11-24T03:06:11Z |
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ISSN 1562-6016. ВАНТ. 2019. №1(119)
PROBLEMS OF ATOMIC SCIENCE AND TECHNOLOGY. 2019, № 1. Series: Plasma Physics (25), p. 187-189. 187
THE ANTIMICROBIAL ACTIVITY OF MAGNETRON SPUTTERED Ag
DOPED ALUMINUM OXIDE COATINGS IN VITRO
V. Safonov
1,2
, N. Donkov
3
, A. Zykova
1,2
, L. Avramov
3
, S. Dudin
2
, S. Yakovin
2
,
H. Naidenski
4
,
I. Avramova
5
1
National Science Center “Kharkov Institute of Physics and Technology”, Kharkiv, Ukraine;
2
V.N. Karazin Kharkiv National University, Kharkiv, Ukraine;
3
E. Djakov Institute of Electronics, Sofia, Bulgaria;
4
Stephan Angeloff Institute of Microbiology, Sofia, Bulgaria;
5
Institute of General and Inorganic Chemistry, Sofia, Bulgaria
E-mail: v_safonov@kipt.kharkov.ua
The effect of Ag-doped aluminium oxide coatings deposited by magnetron sputtering method on the antibacterial
efficiency against Gram-positive, Gram-negative bacteria and fungi has been investigated. The structure and
composition of coatings were analysed by means of scanning electron microscopy (SEM), energy-dispersive X-ray
spectroscopy (EDS), photoelectron spectroscopy (XPS) methods. The results of the study suggest that Ag-doped
aluminium oxide coatings demonstrate improved bactericidal effect and have great potential in various medical
applications.
PACS: 87.80 Rb
INTRODUCTION
The standard methods for sterilization of medical
instruments and products require time, intensive
treatment, and aggressive chemicals using. The
antimicrobial coatings formation on the surface of metal
and plastic medical products is a possible alternative
and effective way to improve the quality of modern
prosthesis, stents, and optical lenses. Nanocomposite
coatings exhibit unique properties [1, 2], which are very
important for next implant and tissue engineering
applications. Recently, it has been reported that Ag ions
could be effective against more than 16 species of
bacteria [3]. To increase the antibacterial properties of
coatings based on Al, Zr, Ti oxides, nitrides and
oxinitrides against different bacterial strains, silver
dopes with bactericidal effect as antibiotics were added
during deposition process [4-9]. The antimicrobial
properties of Ag doped aluminum oxide coatings
deposited by magnetron sputtering method against
representative strains of microorganisms associated with
hospital-acquired infections such as Gram-positive
Staphylococcus aureus, and Gram-negative Escherichia
coli, Pseudomonas aeruginosa bacterium and fungi
Candida albicans were analyzed in vitro study.
1. MATERIALS AND METHODS
Alumina coatings were deposited in a high vacuum
pumping system with a base pressure of about 10
-2
Pa
by ion source-assisted magnetron sputtering [2]. A
combined aluminum/silver target with a different areas
ratio was used.
The microstructure and morphology of the coatings
were studied by JEM-700F scanning electron
microscope. The Energy-dispersive X-ray spectroscopy
(EDS) method with a high-energy electron beam was
used for determination of the elements and the Ag
distribution in the Al2O3-Ag samples. X-ray
photoelectron spectroscopy was carried out using
ESCALAB MkII (VG Scientific) electron spectrometer
using AlKalphaX-ray source (excitation energy
hν=1486.6 eV).
The following microbial strains and microorganisms
were selected: bacteria Gram-positive Staphylococcus
aureus, methicillin resistant strain (MRSA), Gram-
negative Escherichia coli, Pseudomonas aeruginosa
bacterium and fungi Candida albicans from the
Collection of Institute of Microbiology, BAS. The Ag-
doped aluminum oxide coatings deposited by magnetron
sputtering method were testd. The bacterial suspensions
were put on the coated and uncoated surfaces of glass
substrates. 1: 1 to 1: 1000 – the dilutions of the bacterial
suspension that had been in contact with the silver
doped coatings and control for a respective time period
of 0, 1, 2, 5, and 24 hours and from which 25 μl was
plated on Tryptic Soy agar medium Agar for
microbiology (Sigma-Aldrich). After 24 hours of
incubation at 37 °C, the number of bacterial colonies
emerged. The direct microscopic counting of viable
cells by haemocytometer was made. The results were
expressed as CFU/ml (colony-forming units per
milliliter). The statistical correlation of the results of
antibacterial activity tests between the coated samples
and control was determined. Difference was considered
significant at the p < 0.05.
2. RESULTS AND DISCUSSION
Fig. 1 shows SEM images of Ag-doped Al2O3
coatings deposited by magnetron sputtering method.
The coatings surface was smooth and uniform, without
cracks and delamination. EDS spectra reveal the
presents of main characteristic elements such as
aluminum (Al), oxygen (O), silver (Ag). The presence
of silicon (Si), calcium (Ca), sodium (Na) elements
results from the small thickness (0.1 μm) of coating on
the glass substrate.
188 ISSN 1562-6016. ВАНТ. 2019. №1(119)
a
b
Fig. 1. SEM images (a) and EDS spectra (b) of Ag-
doped aluminium oxide coating deposited by magnetron
sputtering method on the glass substrates
The bonding states of the deposited Ag-doped Al2O3-
coatings were characterized by XPS. The high-
resolution photoelectron spectra of Al2p, O1s, Ag3d
were observed. The chemical composition was found to
be close to stoichiometric composition [10]. Fig. 2
shows O1s and Ag3d XPS spectra of the deposited
Al2O3-Ag coating. The O1s high-resolution spectra
demonstrate the peak at binding energy position
E = 531.7 eV, associated with Al-O chemical bond. The
Al2p peak with binding energy position E=75 eV,
which is corresponded to the Al2O3 composition was
detected.
a b
Fig. 2. The high-resolution photoelectron spectra of
O1s (a), Ag3d (b) of the Ag-doped aluminium oxide
coating deposited by magnetron sputtering method on
the glass substrates
The characteristic Ag3d3/2 and Ag3d5/2 spectra (see
Fig. 2,b) are detected at 374.4 and 368.7 eV,
correspondently. Ag3d5/2 spectrum shows broad peak
which can be deconvoluted into three components
corresponding to an Ag peak at 368.2 eV, an Ag2O-
bond peak at 367.7 eV, and a silver oxide (AgO)-bond
peak at 367.1 eV [7].
The bacterial-viability tests in Fig. 3 demonstrate
strong bactericidal activity of Ag-doped aluminium
oxide coating deposited by magnetron sputtering
method against Gram-negative Escherichia coli,
Pseudomonas aeruginosa bacterium.
S.aureu
0.1
1
10
100
1000
10000
100000
1000000
0 h 2 h 5 h 24 h
Time
N
u
m
b
er
o
f
vi
ab
le
b
ac
te
ri
a
(c
fu
/m
l)
control
Al2O3-Ag
a)a)
E.coli
0.1
1
10
100
1000
10000
100000
1000000
10000000
0 h 2 h 5 h 24 h
Time
N
u
m
b
e
r
o
f
vi
ab
le
b
a
ct
er
ia
(c
fu
/m
l)
control
Al2O3-Ag
b)
P.aeruginosa
0.1
1
10
100
1000
10000
100000
1000000
10000000
0 h 2 h 5 h 24 h
Time
N
u
m
b
er
o
f
vi
ab
le
b
ac
te
ri
a
(
cf
u
/m
l) control
Al2O3-Ag
c)
C. albicans
0.1
1
10
100
1000
10000
100000
1000000
10000000
0 h 2 h 5 h 24 h
Time
N
u
m
b
er
o
f
vi
ab
le
b
ac
te
ri
a
(
cf
u
/m
l) control
Al2O3-Ag
d)
Fig. 3. Bacterial-viability tests of Ag-doped aluminium
oxide coating deposited by magnetron sputtering
method on the glass substrates: a) Staphylococcus
aureus, strain 29213 (ATCC), b) Escherichia coli strain
35218 (ATCC), c) Pseudomonas aeruginosa, strain
1390 (ATCC), d) Candida albicans strain
74 (ATCC)
After 5 hours incubation all bacterium were died in
comparison with control samples. In the contrary, the
coatings influence on the Gram-positive Staphylococcus
aureus and fungi Candida albicans was less effective.
This fact confirms that the application of Ag-doped
Al2O3 coatings significantly improved the antibacterial
properties of coatings against Gram-negative bacterium,
as it was previously reported in the studies [3, 4].
ISSN 1562-6016. ВАНТ. 2019. №1(119) 189
CONCLUSIONS
The results demonstrate the principal possibility to
increase the antimicrobial activity of the Ag-doped
aluminum oxide coatings against representative strains
of microorganisms. The effect of the bactericidal action
of coated surfaces results in the lethality of all studied
bacterial strains and fungi during 24 hours of testing
period. The activation of surface antimicrobial
properties of various medical products is very
challenging for many biomedical applications.
ACKNOWLEDGEMENTS
The research was supported by the international
scientific cooperation program of Bulgarian-Ukrainian
Academies of Science, and international scientific
cooperation project between National Academy of
Science of Ukraine and Belarusian Academy of Science
№ 17-3-18.
REFERENCES
1. D.H. Trinh, T. Kubart, T. Nyberg, M. Ottosson,
I. Hultman, H. Hogberg. Direct current magnetron
sputtering deposition of nanocomposite alumina-
zirconia thin films // Thin Solid Films. 2008, v. 516,
p. 8352-8358.
2. V. Safonov, A. Zykova, J. Smolik, R. Rogovska,
V. Lukyanchenko, D. Kolesnikov. Modification of
implant material surface properties by means of oxide
nano-structured coatings deposition // J. Applied
Surface Science. 2014, v. 310, p.174-179.
3. J.H. Hsieh, C.H. Chiu, C. Li, W.Wu, S.Y. Chang.
Development of anti-wear and anti-bacteria TaN-
(Ag,Cu) thin films – a review // Surface and Coatings
Technology. 2013, v. 233, p. 159-168.
4. J. Musil, M. Louda, R. Cerstvy, P. Baroch, I.B. Ditta,
A. Steele, H.A. Foster. Two-functional DC sputtered
Ag-containing TiO2 thin films // Nanoscale Research
Letters. 2009, v. 4, p. 313-320.
5. L.A. Brook, P. Evans, H.A. Foster, M.E. Pemble,
A. Steele, D.W. Sheel, H.M. Yates. Highly bioactive
silver and silver/titania composite films grown by
chemical vapour deposition // Journal of
Photochemistry and Photobiology A. 2007, v. 187, p.
53-63.
6. Y. Huang, X. Zhang, H. Zhang, H. Qiao, T. Jia,
S. Han, Y. Gao, H. Xiao, H. Yang. Fabrication of silver
and strontium-doped hydroxyapatite/TiO2 nanotube
bilayer coatings for enhancing bactericidial effect and
osteoinductivity // Ceramic International. 2017, v. 43,
p. 993-1007
7. Heng-Li Huang, Yin-Yu Chang, Ya-Chi Chen, Chih-
Ho Lai, Michael Y.C. Chen. Cytocompatibility and
antibacterial properties of zirconia coatings with
different silver contents on titanium // Thin Solid Films.
2013, v. 549, p. 108-116.
8. Yin-Yu Chang, Heng-Li Huang, Ya-Chi Chen, Jui-
Ching Weng, Chih-Ho Lai. Characterization and
antibacterial performance of ZrNO–Ag coatings //
Surface and Coatings Technology. 2013, v. 231, p. 224-
228.
9. J.H. Hsieh, C.C. Chang, C. Li, S.J. Liu, Y.K. Chang.
Effects of Ag contents on antibacterial behaviors of
TaON–Ag nanocomposite thin films // Surface and
Coatings Technology. 2010, v. 205, p. S337-S340.
10. A. Zykova, V. Safonov, A. Goltsev, T. Dubrava,
I. Rossokha, J. Smolik, R. Rogovska, S. Yakovin,
D. Kolesnikov, I. Sudzhanskaya, I. Goncharov. The
effect of surface treatment of ceramic oxide coatings
deposited by magnetron sputtering method on the
adhesive and proliferative activity of mesenchymal stem
cells // Surface and Coatings Technology. 2016, v. 301,
p. 14-120.
Article received 09.10.2018
АНТИМИКРОБНАЯ АКТИВНОСТЬ ПОКРЫТИЯ ОКСИДА АЛЮМИНИЯ С СЕРЕБРОМ,
НАНЕСЕННОГО МЕТОДОМ МАГНЕТРОННОГО РАСПЫЛЕНИЯ В ТЕСТАХ IN VITRO
В. Сафонов, Н. Донков, А. Зыкова, Л. Aврамов, С. Дудин, С. Яковин, Х. Найденски, И. Aврамова
Исследовано влияние покрытий оксида алюминия с серебром, нанесенных методом магнетронного
напыления на антибактериальную эффективность против грамположительных, грамотрицательных бактерий
и грибков. Структура и состав покрытий были проанализированы с помощью сканирующей электронной
микроскопии (SEM), энергодисперсионной рентгеновской спектроскопии (EDS), методов фотоэлектронной
спектроскопии (XPS). Результаты исследования позволяют утверждать, что покрытия оксида алюминия с
серебром демонстрируют улучшенный бактерицидный эффект и имеют большой потенциал применения в
различных областях медицины.
АНТИМІКРОБНА АКТИВНІСТЬ ПОКРИТТЯ ОКСИДУ АЛЮМІНІЮ ЗІ СРІБЛОМ,
НАНЕСЕНИМ МАГНЕТРОННИМ РОЗПИЛЕННЯМ У ТЕСТАХ IN VITRO
В. Сафонов, М. Донков, А. Зикова, Л. Aврамов, С. Дудін, С. Яковін, Х. Найденскі, І. Aврамова
Досліджено вплив покриттів оксиду алюмінію зі сріблом, нанесених методом магнетронного напилення
на антибактеріальну ефективність проти грампозитивних, грамнегативних бактерій та грибків. Структура та
склад покриттів були проаналізовані за допомогою скануючої електронної мікроскопії (SEM),
енергодисперсійної рентгенівської спектроскопії (EDS), методів фотоелектронної спектроскопії (XPS).
Результати дослідження дозволяють стверджувати, що покриття оксиду алюмінію зі сріблом демонструють
поліпшений бактерицидний ефект і мають великий потенціал використання в різних галузях медицини.
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