Structural phasic characteristics of nanoparticles oxides Samarium-153 by influence gamma activation
The isotope ¹⁵³Sm (T₁/₂ = 46.3 h, E = 810 keV) which emit is both therapeutic beta and diagnostic gamma energies and it is ideal for therapy plus diagnostic application. The specific activity of ¹⁵³Sm was increased by using the Szilard-Chalmers reaction and nanoparticles Sm₂O₃ after gamma activation...
Saved in:
| Published in: | Problems of Atomic Science and Technology |
|---|---|
| Date: | 2023 |
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Національний науковий центр «Харківський фізико-технічний інститут» НАН України
2023
|
| Subjects: | |
| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/196140 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Structural phasic characteristics of nanoparticles oxides Samarium-153 by influence gamma activation / N.P. Dikiy, N.V. Krasnoselskiy, Yu.V. Lyashko, E.P. Medvedeva, D.V. Medvedev // Problems of Atomic Science and Technology. — 2023. — № 3. — С. 59-61. — Бібліогр.: 8 назв. — англ. |
Institution
Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
nasplib_isofts_kiev_ua-123456789-196140 |
|---|---|
| record_format |
dspace |
| spelling |
Dikiy, N.P. Krasnoselskiy, N.V. Lyashko, Yu.V. Medvedeva, E.P. Medvedev, D.V. 2023-12-10T16:53:07Z 2023-12-10T16:53:07Z 2023 Structural phasic characteristics of nanoparticles oxides Samarium-153 by influence gamma activation / N.P. Dikiy, N.V. Krasnoselskiy, Yu.V. Lyashko, E.P. Medvedeva, D.V. Medvedev // Problems of Atomic Science and Technology. — 2023. — № 3. — С. 59-61. — Бібліогр.: 8 назв. — англ. 1562-6016 PACS: 87.23.-n; 92.40.Qk DOI: https://doi.org/10.46813/2023-145-059 https://nasplib.isofts.kiev.ua/handle/123456789/196140 The isotope ¹⁵³Sm (T₁/₂ = 46.3 h, E = 810 keV) which emit is both therapeutic beta and diagnostic gamma energies and it is ideal for therapy plus diagnostic application. The specific activity of ¹⁵³Sm was increased by using the Szilard-Chalmers reaction and nanoparticles Sm₂O₃ after gamma activation on LAE. It is shown that the isotope ¹⁵³Sm after gamma activation there are no radioactive impurities and no changes of chemical and phasic structure. Ізотоп ¹⁵³Sm (T₁/₂ = 46.3 год, E = 810 кеВ) являється ідеальним емітером для проведення бета-терапії та гамма-діагностики. Питома активність ¹⁵³Sm була підвищена завдяки використанню реакції Сціларда-Чалмерса та наночастинок Sm₂O₃ після гамма-активації на лінійному прискорювачі електронів. Показано, що ізотоп ¹⁵³Sm після гамма-активації не містить радіонуклідних домішок та не втрачає хімічну та фазову структури. en Національний науковий центр «Харківський фізико-технічний інститут» НАН України Problems of Atomic Science and Technology Application of nuclear methods Structural phasic characteristics of nanoparticles oxides Samarium-153 by influence gamma activation Вплив гамма-активації на структурно-фазові характеристики наночастинок ¹⁵³Sm Article published earlier |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| title |
Structural phasic characteristics of nanoparticles oxides Samarium-153 by influence gamma activation |
| spellingShingle |
Structural phasic characteristics of nanoparticles oxides Samarium-153 by influence gamma activation Dikiy, N.P. Krasnoselskiy, N.V. Lyashko, Yu.V. Medvedeva, E.P. Medvedev, D.V. Application of nuclear methods |
| title_short |
Structural phasic characteristics of nanoparticles oxides Samarium-153 by influence gamma activation |
| title_full |
Structural phasic characteristics of nanoparticles oxides Samarium-153 by influence gamma activation |
| title_fullStr |
Structural phasic characteristics of nanoparticles oxides Samarium-153 by influence gamma activation |
| title_full_unstemmed |
Structural phasic characteristics of nanoparticles oxides Samarium-153 by influence gamma activation |
| title_sort |
structural phasic characteristics of nanoparticles oxides samarium-153 by influence gamma activation |
| author |
Dikiy, N.P. Krasnoselskiy, N.V. Lyashko, Yu.V. Medvedeva, E.P. Medvedev, D.V. |
| author_facet |
Dikiy, N.P. Krasnoselskiy, N.V. Lyashko, Yu.V. Medvedeva, E.P. Medvedev, D.V. |
| topic |
Application of nuclear methods |
| topic_facet |
Application of nuclear methods |
| publishDate |
2023 |
| language |
English |
| container_title |
Problems of Atomic Science and Technology |
| publisher |
Національний науковий центр «Харківський фізико-технічний інститут» НАН України |
| format |
Article |
| title_alt |
Вплив гамма-активації на структурно-фазові характеристики наночастинок ¹⁵³Sm |
| description |
The isotope ¹⁵³Sm (T₁/₂ = 46.3 h, E = 810 keV) which emit is both therapeutic beta and diagnostic gamma energies and it is ideal for therapy plus diagnostic application. The specific activity of ¹⁵³Sm was increased by using the Szilard-Chalmers reaction and nanoparticles Sm₂O₃ after gamma activation on LAE. It is shown that the isotope ¹⁵³Sm after gamma activation there are no radioactive impurities and no changes of chemical and phasic structure.
Ізотоп ¹⁵³Sm (T₁/₂ = 46.3 год, E = 810 кеВ) являється ідеальним емітером для проведення бета-терапії та гамма-діагностики. Питома активність ¹⁵³Sm була підвищена завдяки використанню реакції Сціларда-Чалмерса та наночастинок Sm₂O₃ після гамма-активації на лінійному прискорювачі електронів. Показано, що ізотоп ¹⁵³Sm після гамма-активації не містить радіонуклідних домішок та не втрачає хімічну та фазову структури.
|
| issn |
1562-6016 |
| url |
https://nasplib.isofts.kiev.ua/handle/123456789/196140 |
| citation_txt |
Structural phasic characteristics of nanoparticles oxides Samarium-153 by influence gamma activation / N.P. Dikiy, N.V. Krasnoselskiy, Yu.V. Lyashko, E.P. Medvedeva, D.V. Medvedev // Problems of Atomic Science and Technology. — 2023. — № 3. — С. 59-61. — Бібліогр.: 8 назв. — англ. |
| work_keys_str_mv |
AT dikiynp structuralphasiccharacteristicsofnanoparticlesoxidessamarium153byinfluencegammaactivation AT krasnoselskiynv structuralphasiccharacteristicsofnanoparticlesoxidessamarium153byinfluencegammaactivation AT lyashkoyuv structuralphasiccharacteristicsofnanoparticlesoxidessamarium153byinfluencegammaactivation AT medvedevaep structuralphasiccharacteristicsofnanoparticlesoxidessamarium153byinfluencegammaactivation AT medvedevdv structuralphasiccharacteristicsofnanoparticlesoxidessamarium153byinfluencegammaactivation AT dikiynp vplivgammaaktivacíínastrukturnofazovíharakteristikinanočastinok153sm AT krasnoselskiynv vplivgammaaktivacíínastrukturnofazovíharakteristikinanočastinok153sm AT lyashkoyuv vplivgammaaktivacíínastrukturnofazovíharakteristikinanočastinok153sm AT medvedevaep vplivgammaaktivacíínastrukturnofazovíharakteristikinanočastinok153sm AT medvedevdv vplivgammaaktivacíínastrukturnofazovíharakteristikinanočastinok153sm |
| first_indexed |
2025-11-24T15:54:12Z |
| last_indexed |
2025-11-24T15:54:12Z |
| _version_ |
1850849330026512384 |
| fulltext |
ISSN 1562-6016. Problems of Atomic Science and Technology. 2023. №3(145) 59
APPLICATION OF NUCLEAR METHODS
https://doi.org/10.46813/2023-145-059
STRUCTURAL PHASIC CHARACTERISTICS OF NANOPARTICLES
OXIDES SAMARIUM-153 BY INFLUENCE GAMMA ACTIVATION
N.P. Dikiy
1
, N.V. Krasnoselskiy
2
, Yu.V. Lyashko
1
, E.P. Medvedeva
1
, D.V. Medvedev
1
1
National Science Center “Kharkov Institute of Physics and Technology”, Kharkiv, Ukraine;
2
S.P. Grigoriev Institute for Medical Radiology, Kharkiv, Ukraine
E-mail: ndikiy@kipt.kharkov.ua
The isotope
153
Sm (T1/2 = 46.3 h, E = 810 keV) which emit is both therapeutic beta and diagnostic gamma
energies and it is ideal for therapy plus diagnostic application. The specific activity of
153
Sm was increased by using
the Szilard-Chalmers reaction and nanoparticles Sm2O3 after gamma activation on LAE. It is shown that the isotope
153
Sm after gamma activation there are no radioactive impurities and no changes of chemical and phasic structure.
PACS: 87.23.-n; 92.40.Qk
INTRODUCTION
Samarium-153 (
153
Sm) has radiation characteristics
such as the medium-energy beta particle emission
(Emax = 810 keV) which is profitable for treatmen, the
medium-energy gamma quantum (103 keV) which is
suitable for imaging, and the short half-life (46.3 h).
Isotopes which emit therapeutic beta and diagnostic
gamma energies would be ideal for application –
“theranostic”. An ideal theranostic radionuclide should
has optium physical half-life, necessary liner energy and
range in tissues (1 cm), high ratio of non-penetrating to
penetrating, short lived or stable daughter, good and
selective concentration with prolonged retention in
tumor, and minimum uptake by normal tissue [1].
Samarium-153 is potential suitable as an alternative
to
90
Y,
32
P,
90
Sr in different cancer treatment. It has been
widely used for palliative pain treatment bone
metastatic patients but its therapeutic potential has not
been fully utilised for others cases. The imaging
properties of
153
Sm has been proved effective for
gastrointestinal scintigraphy [2].
The main advantages of
153
Sm are the important
features for transarterial radioembolization.
153
Sm is the
major therapeutic agent wich is widely used in the
world just for various bone pain palliative therapy [3].
One of the important features of radioembolic agent
is the particle size. Nowadays the particular attention
give to the particles size especially nanoparticles in
range between 40…80 nm. The nanoparticles may pass
in the tumour capillaries and reach the such
parenchymatous organs such as lungs, kidneys, liver [4].
Nanoparticles with resistivity to physical heat and
body chemicals, biocompatible, non-biodegradable and
easily labelled with radionuclides are highly preference.
Decay properties such as half-life and particles
energy play significant roles in clinical characteristics,
for example, duration of palliative effects and degree of
and time to recovery from myelosuppression.
The particles emissions from
32
P and
89
Sr in bone
and soft tissue are much greater than those of
153
Sm.
High energy particles are associated with greater
marrow toxicity as result of the larger volumes of
marrow exposed to radiation. The shoter physical half-
life of
153
Sm (1.9 days) results in more rapid delivery of
radiation than either
32
P (14.3 days) or
89
Sr (50.5 days).
For example, delivery of 90% of the total dose of
radiation requires approximately 3.5 half-lives of decay,
a time interval of approximately 1 week for
153
Sm.
The purpose of our study was to evaluate for each
sample
153
Sm the presence of radionuclide impurities,
especially the long-lived radionuclides and comparison
of IR spectra nanoparticles initial Sm2O3 and
153
Sm on
the water content before and after gamma activation.
1. MATERIALS AND METHODS
Gamma-activation method used for production
153
Sm with high specific activity that can be increased in
many cases by using the Szilard-Chalmers process
[5–7].
In that experiment the nanoparticles (50…80 nm)
Sm2O3 and clinoptilolite (80 nm) used. On LAE with
E = 23 MeV and curent 700 µA it is possible to produce
1 Ci
153
Sm during day by using of Sm2O3 (40 g) of
natural isotope composition.
The activity of
153
Sm obtained in nuclear reaction
154
Sm(γ,n)
153
Sm measured by Ge(Li)-detector with
volume 50 cm
3
and with energy resolution 3.2 keV in
the area of 1332 . To reduce the influence of backgrond,
the detector is equipped with a three-layer Pb-Cu-Al
protection.
Nanoparticles Sm2O3 and clinoptilolite used as
donor and acceptor, respectively. For the concentration
of recoil nucleir in among donor, nanoparticles sizes
Sm2O3, containing an activatable element, must be less
than or equal to the range of racoil nuclei.
The structure and phase composition of
nanoparticles Sm2O3 and
153
Sm investigated by infrared
(IR) spectrophotometer “Specord-75” in the frequency
600…4000 cm
-1
on the compressed tablets from mixture
KBr (100 mg sample) [8].
2. RESULTS AND DISCUSSION
Gamma ray spectrum of
153
Sm is shown in Fig. 1.
The most dominant peaks observed were at 103 and
69.5 keV and two other significant peaks were 41 and
45 keV. These peaks resulted from K-shell
characteristic X-ray following radioactive decay. There
are not radionuclide impurity in the
153
Sm sample.
mailto:ndikiy@kipt.kharkov.ua
60 ISSN 1562-6016. Problems of Atomic Science and Technology. 2023. №3(145)
Fig. 1. Gamma ray spectrum of natural Sm after
activation bremsstruhlung energy 11.5 MeV
Gamma ray spectrum of native non activate
clinoptilolite as acceptor for
153
Sm is shown in Fig. 2.
Fig. 2. Gamma ray spectrum of natural clinoptilolite
The measurement of gamma spectra of natural
clinoptilolite gamma spectrum was shown the
folllowing gamma lines of
228
Ac and
40
K for
214
Pb,
214
Bi,
212
Pb,
208
Tl. The content of Th, U was conformed with
distribution theirs in earth`scrust (Th ~ 1.0 10
-5
,
U ~ 3.6 10
-6
g/g). The ratio Th/U was 3.87 for natural
clinoptilolite sample and for earth`scrust of average
value – 2.78.
IR spectrum of the nanoparticle sample Sm2O3 was
compared to IR spectrum of the same sample after
activation by bremsstruhlung energy 11.5 MeV. As
shown in Figs. 3 and 4. IR spectra of samples before
and after activation are nearly identical. Gamma
activation did not destroy the chemical structure and the
functional groups. The intensity bands 3200 and
3400 cm
-1
also indicated that the water content during
gamma activation of samples was not changed.
Fig. 3. IR spectra of nanoparticles Sm2O3 before
activation bremsstruhlung energy 11.5 MeV
The presence in the IR spectrum of absorption bands
of medium intensity in the frequency range of 2000 and
2800 cm
-1
small peaks which is associated with an
impurity OH
-1
groups.
Fig. 4. IR spectra of nanoparticles Sm2O3 after
activation bremsstruhlung energy 11.5 MeV
CONCLUSIONS
Photo-nuclear technology for produce isotopes
153
Sm with high specific activity by using the Szilard-
Chalmers process and nanoparticles Sm2O3 was
elaborated. Elemental analysis and method of infrared
spectrocopy showed no radioactive impurities and no
major differences observed between chemical structure,
functional groups and water content after gamma
activation of nanoparticles Sm2O3.
REFERENCES
1. SM Qaim. Therapeutic radionuclides and nuclear
data. // Radiochim. Acta. 2001, v. 89, p. 297-302.
2. C.H. Yeong, B.J. Abdullah, K.H. Ng, et al.
Production and first use of
153m
SmCl3-ion exhande
resin capsule formulation for assessing
gastrointestial motility // Appl. Radiat. Isot. 2012,
v. 70(3), p. 450-455.
3. A.N. Stefini Therapy of metastatic bone pain // J.
Nucl. Med. 2001, v. 42(6), p. 895-906.
4. D.H. Kim, J. Chen, R.A. Omary, et al. MRI visible
drug eluting magnetic microspheres foe transcatheter
intra-arterial delivery to liver tumors // Theranostic.
2015, v. 5(5), p. 477-488.
5. L. Szilard, T.A. Chalmers. Detection of neutrons
liberated from beryllium by gamma rays: a new
thechnique for inducing radiofctivity // Nature.
1934, v.134, p. 494-495.
6. S.K. Zeisler, K. Weber. Szilard-Chalmers effect in
holmium complexes // J. Radioanalyt. and Nuclear
Chem. 1998, v. 227, N 1, p. 105-109.
7. N.P. Dikiy, A.N. Dovbnya, N.V. Krasnoselskiy, et
al. Photonuclear method of production of free
153
Sm
by use of nanoparticles of samarium oxide and
clinotilolite / / PAST. Series “Nuclear Physics
Investigations” (103). 2016, N 3(66), p. 162-165.
8. I.K. Abdukadyrova. IR spectroscopy application in
studies on structural in verious quarts samples // J. of
Applied Spectroscopy. 2007, v.76, N 1, p. 122-125.
Article received 11.04.2023
ISSN 1562-6016. Problems of Atomic Science and Technology. 2023. №3(145) 61
ВПЛИВ ГАММА-АКТИВАЦІЇ НА СТРУКТУРНО-ФАЗОВІ ХАРАКТЕРИСТИКИ
НАНОЧАСТИНОК
153
Sm
М.П. Дикий, М.В. Красносельський, Ю.В. Ляшко, О.П. Медведєва, Д.В. Медведєв
Ізотоп
153
Sm (T1/2 = 46.3 год, E = 810 кеВ) являється ідеальним емітером для проведення бета-терапії та
гамма-діагностики. Питома активність
153
Sm була підвищена завдяки використанню реакції Сціларда-
Чалмерса та наночастинок Sm2O3 після гамма-активації на лінійному прискорювачі електронів. Показано,
що ізотоп
153
Sm після гамма-активації не містить радіонуклідних домішок та не втрачає хімічну та фазову
структури.
|