Application of the surface plasmon resonance phenomenon for early detection and determination of the drug concentration for treating the relapses of malignant tumors

• Published in: Semiconductor Physics Quantum Electronics & Optoelectronics
• Date: 2020
• Main Authors: Gridina, N.Ya., Maslov, V.P., Ushenin, Yu.V., Rozumenko, V.D., Morozov, A.N.
• Format: Article
• Language: English
• Published: Інститут фізики напівпровідників імені В.Є. Лашкарьова НАН України 2020
• Subjects: Optoelectronics and optoelectronic devices
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/215656
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Application of the surface plasmon resonance phenomenon for early detection and determination of the drug concentration for treating the relapses of malignant tumors / N.Ya. Gridina, V.P. Maslov, Yu.V. Ushenin, V.D. Rozumenko, A.N. Morozov // Semiconductor Physics Quantum Electronics & Optoelectronics. — 2020. — Т. 23, № 1. — С. 85-90. — Бібліогр.: 19 назв. — англ.

One of the promising directions in oncology is the development of methods for the treatment of malignant tumors with an account of the mechanisms of their genesis and focused on the correction of definite pathogenesis components, while being nontoxic for other organs and tissues. Investigated in this work was the possibility of using the phenomenon of surface plasmon resonance (SPR) for the analysis of blood inherent to patients with glioma of different degrees of malignancy by studying the level of aggregation of blood cells. For this aim, we ascertained a correlation between SPR characteristics and the condition of the patient, as well as the choice of the drug's efficient concentration. The works were performed based on positive results obtained in preliminary experiments with lab rats, which were carried out in cooperation with the State Institution “A.P. Romodanov Institute of Neurosurgery, NAMS of Ukraine”, and V. Lashkaryov Institute of Semiconductor Physics, NAS of Ukraine, by using the device “Plasmon”. It has been experimentally shown that, when using the chosen drug by treated patients, the signs of toxic action of verapamil hydrochloride are absent, and the life span is 10 months longer as compared with the group of patients that are not treated with this drug in low concentrations during the postoperative period.