Системные биохимические нарушения при экспериментальном аллергическом энцефаломиелите

• Date: 2007
• Main Authors: Кучмеровская, Т.М., Гурина, Н.М., Шиманский, И.А., Донченко, Г.В., Супрун, С.М., Клименко, А.П.
• Format: Article
• Language: Russian
• Published: Видавничий дім "Академперіодика" НАН України 2007
• Subjects: Біохімія
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/3151
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Системные биохимические нарушения при экспериментальном аллергическом энцефаломиелите / Т.М. Кучмеровская, Н.М. Гурина, И.А. Шиманский, Г.В. Донченко, С.М. Супрун, А.П. Клименко // Доп. НАН України. — 2007. — № 9. — С. 155-160. — Бібліогр.: 15 назв. — рос.

Reduced levels of total lipids and cholesterol in blood serum were shown after 10 days of
 experimental allergic encephalomyelitis (EAE) induction. The elevated content of blood serum
 phospholipids was observed after 18 days of EAE duration. These alterations were accompanied
 by the progressive increase in both the total proteolytic activity and acid phosphatase activity
 with a decreasing effect on alkaline phosphatase in blood serum. Compared to control, the blood
 content of vitamin B12 was twice lower in the period as early as 10 days after EAE induction.
 Our findings suggest the presence of system biochemical impairments, which most likely reflect
 the degree of EAE-related destructive changes in brain and may be of significance as diagnostic
 and prognostic criteria for multiple sclerosis management.