Hodgkin’s lymphoma: the role of cell surface receptors in regulation of tumor cell fate

• Published in: Experimental Oncology
• Date: 2010
• Main Authors: Yurchenko, M., Sidorenko, S.P.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2010
• Subjects: Reviews
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/32298
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Hodgkin’s lymphoma: the role of cell surface receptors in regulation of tumor cell fate / M. Yurchenko, S.P. Sidorenko // Experimental Oncology. — 2010. — Т. 32, № 4. — С. 214–223. — Біліогр.: 104 назв. — англ.

The hallmark of Hodgkin’s lymphoma (HL) are mononucleated Hodgkin’s cells and multinucleated Reed-Sternberg (HRS) cells, which usually account for only about 1% of cells in the tumor tissue. The majority of HRS cells in classical HL are derived from germinal centre B cells that have acquired disadva...